A0A7W4V0F7 · A0A7W4V0F7_9MICO

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site27Mg2+ (UniProtKB | ChEBI)
Site32Substrate discrimination
Binding site121Mg2+ (UniProtKB | ChEBI)
Active site122

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • ORF names
      FHX49_000134

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 27099
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microbacterium

Accessions

  • Primary accession
    A0A7W4V0F7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-203UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    45,473
  • Last updated
    2021-06-02 v1
  • Checksum
    89E2D9F5FF81FA5C
MGKGDGRGRLTSPPDVDDTGAHVLHVDMDAFYPSVEILDNPSLRGKPIIIGSTEGRSVVSSASYEARVYGVRSAMPVSQALRLCPKAIVVPPHFARYSELSRQVMAVFHEVTPLVEPLSIDEAFLDVSGSRRLWGRPREIAQMLRARVHERTGLTCSVGAAATKHVAKMASTLSKPDGLLVVSAASTADFLSPLSVRNLWGVGPKSADVLEARGIRVVADVLTTPIEVLQRALGVSMGERVWQLARGIDTRTVQTERVEKSVGHEETFEVDVTDPDALRAELRRLADRVGVRLRRHEWSAQTVSIKIRFADFTTVTRGLTLAEPSNVSQRLGDVALDLFAQLHRGQPVRLVGVRAENLRPASVQGGGLWDDDAEWRRVDGALDGAATRFGVGAITRAALLGGRKSGSSLPSHPRPDADFS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACHWQ010000001
EMBL· GenBank· DDBJ
MBB2974593.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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