A0A7W3VKV1 · A0A7W3VKV1_9FLAO
- ProteinProtoheme IX farnesyltransferase
- GenecyoE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids304 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Miscellaneous
Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Catalytic activity
- heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
Pathway
Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protoheme IX farnesyltransferase activity | |
Biological Process | heme A biosynthetic process | |
Biological Process | heme O biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtoheme IX farnesyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Myroides
Accessions
- Primary accessionA0A7W3VKV1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 54-77 | Helical | ||||
Sequence: MTILALAIGGYCMVGASNVYNQII | ||||||
Transmembrane | 98-120 | Helical | ||||
Sequence: VKPTPAFILAVVLTLLGIAILYA | ||||||
Transmembrane | 126-143 | Helical | ||||
Sequence: AMFGAISIFLYTSVYTPL | ||||||
Transmembrane | 150-168 | Helical | ||||
Sequence: SVFVGAFPGAIPFMLGWVA | ||||||
Transmembrane | 180-200 | Helical | ||||
Sequence: LFLIQFFWQFPHFWAIGWFLY | ||||||
Transmembrane | 221-240 | Helical | ||||
Sequence: LTQIILYTIWLIIVSIFPVF | ||||||
Transmembrane | 246-270 | Helical | ||||
Sequence: LYLTPIAAGLVLLAGIWMLTAAVKL | ||||||
Transmembrane | 282-299 | Helical | ||||
Sequence: LMLVSVTYISLIQIIYVL |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length304
- Mass (Da)33,811
- Last updated2021-06-02 v1
- Checksum9D239F43C0EF3D39