A0A7W3MWM8 · A0A7W3MWM8_9ACTN

Function

function

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site6a divalent metal cation (UniProtKB | ChEBI)
Binding site6-84-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site8a divalent metal cation (UniProtKB | ChEBI)
Site33Transition state stabilizer
Binding site33-344-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site41a divalent metal cation (UniProtKB | ChEBI)
Binding site55-574-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site129-1324-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Site130Transition state stabilizer
Binding site1394-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Molecular Functionmetal ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • EC number
  • Short names
    MECDP-synthase
    ; MECPP-synthase
    ; MECPS

Gene names

    • Name
      ispF
    • ORF names
      HNR21_002146

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 45823
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Thermomonosporaceae > Thermomonospora

Accessions

  • Primary accession
    A0A7W3MWM8

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-1512-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Sequence similarities

Belongs to the IspF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    155
  • Mass (Da)
    15,423
  • Last updated
    2021-06-02 v1
  • Checksum
    91AD2B5F36AD831B
MGVGTDVHPFGSGRPLWVAGLLWPGEGDGLTGHSDGDVAAHAACDALLSAAGLGDLGAVFGTADPRWRGASGTDLLREVARLLTEGGWTIGNVAIQVIGNRPKIGRRRAEAEKVLGEALGGAPVSLSATTTDGLGLTGRGEGLAAIATALVLPPG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACJII010000001
EMBL· GenBank· DDBJ
MBA9003264.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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