A0A7W2ILR6 · A0A7W2ILR6_9BURK
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids238 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 54 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 55 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 59 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 74 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 135-142 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TGNPFFTT | ||||||
Binding site | 162 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 168 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 171 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Oxalobacteraceae > Telluria group > Rugamonas
Accessions
- Primary accessionA0A7W2ILR6
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-216 | Aspartate/glutamate/uridylate kinase | ||||
Sequence: KRVLLKLSGEALMGDDPYGINRGTIERMVADVAEVAKMGVELAIVIGGGNIFRGVAPGAQGMDRATADYMGMLATVMNALALADAMRHVGITARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGSEMSAEIVLKATKVDGVYTADPKKDPHATLFQTITFDEAIAKHLQVMDATAFALCRDQKLPIKVFS |
Sequence similarities
Belongs to the UMP kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length238
- Mass (Da)25,389
- Last updated2021-06-02 v1
- Checksum357ACD663478DA70