A0A7W2CVX7 · A0A7W2CVX7_9ACTN

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site240substrate
Binding site262Zn2+ (UniProtKB | ChEBI)
Binding site262substrate
Binding site265Zn2+ (UniProtKB | ChEBI)
Binding site265substrate
Active site332Proton acceptor
Active site333Proton acceptor
Binding site333substrate
Binding site366Zn2+ (UniProtKB | ChEBI)
Binding site366substrate
Binding site420substrate
Binding site425Zn2+ (UniProtKB | ChEBI)
Binding site425substrate

GO annotations

AspectTerm
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • ORF names
      H1V43_01600

Organism names

Accessions

  • Primary accession
    A0A7W2CVX7

Proteomes

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    47,220
  • Last updated
    2021-06-02 v1
  • Checksum
    0A67AB97210CB97D
MISRIDLRGDALPEGPALRDLLPRADFDVAAALEKVRPICEAVHHRGDAALIDYAEKFDGVRLDQVRVPAAALTRALEELNPAVRAGLEESIRRARIVHREQRRTTHTTQVVPGGTVTEKWVPVERVGLYAPGGRAVYPSSVIMNVVPAQEAGVPSMALASPAQKDFGGLPHPTILAACALLGIDEVYAAGGATAVAMFAYGTESCAPANMVTGPGNIWVAAAKRYFTGRIGIDAEAGPTEIAILADDTADPAHVASDLISQAEHDPLAAAVLVTDSPDLADAVEKELEPQVAATKHIEDRIVPALSGKQSAIVLVDGLEEGLRVVDAYGAEHLEIQTADAAAVADRVKNAGAIFVGPWAPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTRDALAEVAHHVVTLAEAEDLPAHGAAVKARFAGGEQDRRSGWKVPESK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACEQY010000001
EMBL· GenBank· DDBJ
MBA4860090.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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