A0A7W2CVX7 · A0A7W2CVX7_9ACTN
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids450 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 240 | substrate | ||||
Sequence: T | ||||||
Binding site | 262 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 262 | substrate | ||||
Sequence: Q | ||||||
Binding site | 265 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 265 | substrate | ||||
Sequence: H | ||||||
Active site | 332 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 333 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 333 | substrate | ||||
Sequence: H | ||||||
Binding site | 366 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 366 | substrate | ||||
Sequence: D | ||||||
Binding site | 420 | substrate | ||||
Sequence: E | ||||||
Binding site | 425 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 425 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces > Streptomyces himalayensis
Accessions
- Primary accessionA0A7W2CVX7
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length450
- Mass (Da)47,220
- Last updated2021-06-02 v1
- Checksum0A67AB97210CB97D