A0A7V3RZT2 · A0A7V3RZT2_UNCDE

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site111Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site147substrate
Binding site173substrate
Site183-184Cleavage; by autolysis
Active site184Nucleophile
Binding site184substrate
Binding site269substrate
Binding site402substrate
Binding site407substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      ENW97_06355

Organism names

Accessions

  • Primary accession
    A0A7V3RZT2

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50316620041-183Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5031662003184-407Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    407
  • Mass (Da)
    43,790
  • Last updated
    2021-06-02 v1
  • Checksum
    4F39251890E3F547
MPEKLTPPRGFLFAGSNVSIKRPGKNDLGVIISESEASAAAVFTSNLFQAAPVLISRRRIRRGKAWAILVNSGNANCGTGKAGLEAARKTGAALARHLCINQSSILLASTGVIGEPLPYKKIIRGIPKLLERASPRGYEDFETAIMTTDTRKKISSRVFTIRGKEVRLLGLAKGAGMIQPQMATMLGFVLTDAELKPGHLAKLLKQSADVSFNRITIDGDTSTNDTVFALANGASRVAFAPDKPGWNRFSNALKEVCLELAQMIVADGEGASRWFYVQVSGAGSDSEAEKIARRIANSPLVKTAISAADPNWGRIIAAAGISGARFDVRKTRLELIAADGGRRIEILKGGARSSSYQGRNKEDEAARVLSRSGFRIVFDAGRGKGDFEILTCDFTQEYVKINAEYRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DTMG01000344
EMBL· GenBank· DDBJ
HGF02150.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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