A0A7U9QDB4 · A0A7U9QDB4_ECOLX

Function

function

Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionphosphotransferase activity, phosphate group as acceptor
Molecular Functionundecaprenyl-diphosphatase activity
Biological ProcessGram-negative-bacterium-type cell outer membrane assembly
Biological Processlipid A biosynthetic process
Biological Processlipopolysaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid A 1-diphosphate synthase
  • EC number
  • Alternative names
    • Kdo(2)-lipid A phosphotransferase
    • Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase

Gene names

    • Name
      lpxT
    • ORF names
      ECKIH15140_02703

Organism names

  • Taxonomic identifier
  • Strain
    • KIH15-140
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A7U9QDB4

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Note: Transferase activity takes place on the periplamic side of the inner membrane.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-24Helical
Transmembrane63-81Helical
Transmembrane93-113Helical
Transmembrane161-182Helical
Transmembrane191-212Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain94-210Phosphatidic acid phosphatase type 2/haloperoxidase

Sequence similarities

Belongs to the LpxT phosphotransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    26,759
  • Last updated
    2021-06-02 v1
  • Checksum
    A27F9560A1417D09
MIKNLPQIVLLNIVGLALFLSWYIPVNHGFWLPIDADIFYFFNQKLVESKAFLWLVALTNNRAFDGCSLLAMGMLMLSFWLKENAPGRRRIVIIGLVMLLTAVVLNQLGQALIPVKRASPTLTFTDINRVSELLSVPTKDASRDSFPGDHGMMLLIFSAFMWRYFGKVAGLIALIIFVVFAFPRVMIGAHWFTDIIVGSMTVILIGLPWVLLTPLSDRLITFFDKSLPGKNKHFQNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BJSI01000104
EMBL· GenBank· DDBJ
GEG55247.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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