A0A7U4SXF5 · A0A7U4SXF5_STAAU

  • Protein
    Histidinol dehydrogenase
  • Gene
    hisD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site117NAD+ (UniProtKB | ChEBI)
Binding site178NAD+ (UniProtKB | ChEBI)
Binding site201NAD+ (UniProtKB | ChEBI)
Binding site224substrate
Binding site246Zn2+ (UniProtKB | ChEBI)
Binding site246substrate
Binding site249Zn2+ (UniProtKB | ChEBI)
Binding site249substrate
Active site314Proton acceptor
Active site315Proton acceptor
Binding site315substrate
Binding site348Zn2+ (UniProtKB | ChEBI)
Binding site348substrate
Binding site402substrate
Binding site407Zn2+ (UniProtKB | ChEBI)
Binding site407substrate

GO annotations

AspectTerm
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • ORF names
      GQX37_00840

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UE1097
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A7U4SXF5

Proteomes

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil77-104

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    46,237
  • Last updated
    2021-06-02 v1
  • Checksum
    105A61EC25F5F0A2
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQMNQQLEESVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIVYDVFAQAEHDELARTYVISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACHVMNTIAPEHASIQTVNPQPYIEKVKYVSALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFDQIADSAQHIAHVEALYNHQQSILIRQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAANEC010000013
EMBL· GenBank· DDBJ
NUY11110.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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