A0A7U4SXF5 · A0A7U4SXF5_STAAU
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 117 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 178 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 201 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 224 | substrate | ||||
Sequence: T | ||||||
Binding site | 246 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 246 | substrate | ||||
Sequence: Q | ||||||
Binding site | 249 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 249 | substrate | ||||
Sequence: H | ||||||
Active site | 314 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 315 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 315 | substrate | ||||
Sequence: H | ||||||
Binding site | 348 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 348 | substrate | ||||
Sequence: D | ||||||
Binding site | 402 | substrate | ||||
Sequence: E | ||||||
Binding site | 407 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 407 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A7U4SXF5
Proteomes
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 77-104 | |||||
Sequence: LQQSYERIKAYQESIKQMNQQLEESVEC |
Sequence similarities
Belongs to the histidinol dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)46,237
- Last updated2021-06-02 v1
- Checksum105A61EC25F5F0A2