A0A7U3VU06 · A0A7U3VU06_9GAMM

Function

function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentglycine cleavage complex
Molecular Functionglycine binding
Molecular Functionglycine dehydrogenase (decarboxylating) activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine decarboxylation via glycine cleavage system

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycine dehydrogenase (decarboxylating)
  • EC number
  • Alternative names
    • Glycine cleavage system P-protein
    • Glycine decarboxylase
    • Glycine dehydrogenase (aminomethyl-transferring)

Gene names

    • Name
      gcvP
    • ORF names
      CVPH_0995

Organism names

Accessions

  • Primary accession
    A0A7U3VU06

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue692N6-(pyridoxal phosphate)lysine

Interaction

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-430Glycine cleavage system P-protein N-terminal
Domain464-721Glycine cleavage system P-protein N-terminal
Domain759-880Glycine dehydrogenase C-terminal

Sequence similarities

Belongs to the GcvP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    937
  • Mass (Da)
    103,337
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    52860A3B7959973EDC4EC99BDF0DB578
MSNEFLARHLGPSKSDIETMLSSIGCLSVDEVISKTVPKNILFGNRMALDEGMTERDTLALASSLAAKNILATNFIGQGYYGTLMPSVIQRNILENPGWYTAYTPYQAEISQGRLEMLLNFQQMIIDLTGMDISNASLLDEPTACAEAMMMAKRANRKNKSNCFLININTHPQTITILQTRAKPLGIELIIKDIQHDDFSSCFACLMQYPGTNGDVRDLTADITRAKNNNVLTIVACDLLALTLLKTPAEMGADIAVGSSQRFGVPMGFGGPHAAFLSARDTFKRMIPGRLIGMSQDVLGNPAMRMSLQTREQHIRRDKATSNICTAQVLLAVLAAAYGIYHGAKGLKKIALSVHAKANNLAKSLLDAGFELAAEQFFDTITINTTNAVSLFNTAQSNNINLRLINDNQLSIALDETTTVDELSRLVSILSTDKTVYYQSENFLLNITKNNLRTSDYLTHPVFSNYHCETEMMRYLKRLENKDIALNHSMIALGSCTMKLNAATQMYPITLTGFSDLHPYAPENQTKGYQQLFKDLEQALVEVTGYDAVSLQPNAGSQGEFAGLLAIKSYHQSKGEEGRNICLIPQSAHGTNPASAVMAGMKVVIVKCDESGNIDIQDLTTKAEKYADELSAIMVTYPSTHGVFEVEIKQICEIIHTHGAQVYLDGANLNAMVGITRMGEFGADVSHINLHKTFAIPHGGGGPGMGPIGVKVHLKEFLPGNPLIKDSNAVSAAMYGSASILPISWSYIKLLGKYGMQRSTEVAIVSANYIANELKDYFPILYQGEHNMVAHECIIDIRPLKEQSGISEEDIAKRLMDYGFHSPTMSFPVAGTLMIEPTESESLCEINRFIKAMISIYVEIQKVIKGEWDKDNNPLKNAPHTAIEMAGQWQYPYSREEALYPVDSLKQNKYFPPVKRIDNMYGDRNLFCSCPDINDFE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012977
EMBL· GenBank· DDBJ
BBB22951.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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