A0A7U3VU06 · A0A7U3VU06_9GAMM
- ProteinGlycine dehydrogenase (decarboxylating)
- GenegcvP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids937 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H+ = N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | glycine cleavage complex | |
Molecular Function | glycine binding | |
Molecular Function | glycine dehydrogenase (decarboxylating) activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine dehydrogenase (decarboxylating)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria
Accessions
- Primary accessionA0A7U3VU06
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 692 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-430 | Glycine cleavage system P-protein N-terminal | |||
Domain | 464-721 | Glycine cleavage system P-protein N-terminal | |||
Domain | 759-880 | Glycine dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the GcvP family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length937
- Mass (Da)103,337
- Last updated2021-09-29 v1
- MD5 Checksum52860A3B7959973EDC4EC99BDF0DB578
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012977 EMBL· GenBank· DDBJ | BBB22951.1 EMBL· GenBank· DDBJ | Genomic DNA |