A0A7U3V2W5 · A0A7U3V2W5_9GAMM

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-tyrosyl-tRNA(Tyr) deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase
      (EC:3.1.1.-
      ) . EC:3.1.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      dtd
    • ORF names
      CVPH_0867

Organism names

Accessions

  • Primary accession
    A0A7U3V2W5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif137-138Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    15,941
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    DF8A3D02C1D26919F04BC508A65EE428
MKALIQRVSNAKVEVDGKVTEEIKQGILVFLGFEKNDEKLQVDKMIKKLLIYRVFAGEQEKMNLSIKEVLGGILVVSQFTLAADTNSGARAGFSTAKSPEQAKVLFDYFLTQMRADYHKVASGVFGADMQVSLTNDGPATFLLSC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012977
EMBL· GenBank· DDBJ
BBB22851.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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