A0A7U3TGT9 · A0A7U3TGT9_BOVIN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 103_LCO1490_F01_16.ab1
    • 25_LCO1490_F02_17.ab1
    • 34_LCO1490_E09_15.ab1
    • 35_LCO1490_F09_18.ab1
    • 39_LCO1490_B10_04.ab1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A7U3TGT9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-30Helical
Transmembrane51-75Helical
Transmembrane95-118Helical
Transmembrane130-150Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-152Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    152
  • Mass (Da)
    16,243
  • Last updated
    2021-06-02 v1
  • Checksum
    994137416FA558F1
YNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue152

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MW475447
EMBL· GenBank· DDBJ
QQO99921.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475448
EMBL· GenBank· DDBJ
QQO99922.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475449
EMBL· GenBank· DDBJ
QQO99923.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475450
EMBL· GenBank· DDBJ
QQO99924.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475451
EMBL· GenBank· DDBJ
QQO99925.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475452
EMBL· GenBank· DDBJ
QQO99926.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475453
EMBL· GenBank· DDBJ
QQO99927.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475454
EMBL· GenBank· DDBJ
QQO99928.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475455
EMBL· GenBank· DDBJ
QQO99929.1
EMBL· GenBank· DDBJ
Genomic DNA
MW475456
EMBL· GenBank· DDBJ
QQO99930.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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