A0A7T7GVI0 · A0A7T7GVI0_9LECA
- ProteinDNA replication licensing factor MCM7
- GeneMCM7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids145 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | MCM complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | single-stranded DNA binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA replication initiation | |
Biological Process | DNA strand elongation involved in DNA replication | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | double-strand break repair via break-induced replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication licensing factor MCM7
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Lecanoromycetes > OSLEUM clade > Lecanoromycetidae > Lecanorales > Lecanorineae > Parmeliaceae > Usnea
Accessions
- Primary accessionA0A7T7GVI0
Subcellular Location
Structure
Sequence
- Sequence statusFragment
- Length145
- Mass (Da)16,356
- Last updated2021-06-02 v1
- ChecksumECB855BABA1517A1
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 145 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MT439137 EMBL· GenBank· DDBJ | QQM16434.1 EMBL· GenBank· DDBJ | Genomic DNA |