A0A7T7GVI0 · A0A7T7GVI0_9LECA

  • Protein
    DNA replication licensing factor MCM7
  • Gene
    MCM7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic activity

GO annotations

AspectTerm
Cellular ComponentMCM complex
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular Functionsingle-stranded DNA binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA replication initiation
Biological ProcessDNA strand elongation involved in DNA replication
Biological ProcessDNA unwinding involved in DNA replication
Biological Processdouble-strand break repair via break-induced replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM7
  • EC number

Gene names

    • Name
      MCM7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 198BR
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Lecanoromycetes > OSLEUM clade > Lecanoromycetidae > Lecanorales > Lecanorineae > Parmeliaceae > Usnea

Accessions

  • Primary accession
    A0A7T7GVI0

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-94MCM OB

Sequence similarities

Belongs to the MCM family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    145
  • Mass (Da)
    16,356
  • Last updated
    2021-06-02 v1
  • Checksum
    ECB855BABA1517A1
CGCEIFQPVTSKQFTPMTECPSDECKQNNSKGQLFLSTRASKFLPFQEVKIQEMADQVPVGHIPRTLTVHCHGTLTRQINPGDVIDVAGIFLPTPYTGFKAIRAGLLTDTYLEAQHVNQHKKAYDDLVFDAKTFRRIEQYKHSGQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue145

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT439137
EMBL· GenBank· DDBJ
QQM16434.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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