A0A7T7CDD4 · A0A7T7CDD4_9BACI

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1842100200300400500600700800
TypeIDPosition(s)Description
Binding site86ATP (UniProtKB | ChEBI)
Binding site104-108ATP (UniProtKB | ChEBI)
Binding site493ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      HUG15_21475

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC5-3
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Salicibibacter

Accessions

  • Primary accession
    A0A7T7CDD4

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain2-571SecA family profile
Domain88-246Helicase ATP-binding
Domain411-576Helicase C-terminal
Region788-842Disordered
Compositional bias802-823Basic and acidic residues

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    842
  • Mass (Da)
    96,082
  • Last updated
    2021-09-29 v1
  • Checksum
    C22291EC34F5EBA7
MIGLIKKVIGDTDQRKTKKMQKTVDEIDGYANEMKLLSDTDLAAKTENFKARYNGGEDLDSLLPEAFAVVREASTRVLGLTPYPVQLMGAIVLHHGDTAEMKTGEGKTLVATMPVYLNALTGRGVHIVTVNDYLARRDSEDMGRLYNFLGLTVGLNEKGMSKDEKREAYACDVMYGTNNEFGFDYLRDNMVLYKEQMVQRKLHYAIVDEVDSILIDEARTPLIISGSVEQSTEMYVQADGFVRLLKEEEDYTYEEKSKNVRLTEEGVNKAENYFNLNNLYDQGNVQLTHNINQSLKAHRAMQRDDDYVVEDGDVVIVDSFTGRLMKGRRYGDGLHQAIEAKEQLPIKKESMTLASITFQNFFRMYEKLAGMTGTAKTEEEELQNIYNMNVIAIPTNEPIVREDKADLIYKTMDAKFKAVADDIKEIHQRGQPILVGTASVDTSEYVSKLLKKRKVPHDVLNAKHHANEAEIIKNAGQKNAVTIATNMAGRGTDIKLGEGVPELGGLFVIGTERHESRRIDNQLRGRSGRQGDPGVSQFYLSMEDVLMRRFGSENMQNMLNKMGMEEDTPLESRMVSRAVEQSQKRVEGHNFDARKQILEYDDVMREQRDIIYEQRMEVLESENLEEIVQGMINNVVDRTVARFTSEEEVPEDWDLAGLVSELNAMVLYNGDITQNDLYGLEQDEMQELVRGKAEANYKAKEAEIGEEKMREFEKVIMLRAVDRKWMNHIDQMDQLRQGIHLRAYGQSNPLRDYRFEGYNMFEDMIASIEEEVSRYVIKARLRNNMQREAVADENKSQAVHGNNNKEQEKKKKQPIRKEKQVGRNEPCPCGSGKKYKHCHGAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias802-823Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP054705
EMBL· GenBank· DDBJ
QQK77894.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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