A0A7T6Z9D3 · A0A7T6Z9D3_9BACI

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

118920406080100120140160180
TypeIDPosition(s)Description
Binding site11-13N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site64(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site89-92(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site106(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site108Proton donor
Site144Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      HUG20_05040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC21-4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Salicibibacter

Accessions

  • Primary accession
    A0A7T6Z9D3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-181Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    21,089
  • Last updated
    2021-09-29 v1
  • Checksum
    3C0AC45DCEE8C9BB
MRIALFASGTGSNVESILKAIREQKIDAVPVFVFSDRPDASVLEKAKRYEVLTHTFQPRDFDSKQQYEESLLQLLEKNDVQWVILAGYMRLLGATIVEPYAHQIVNIHPSLLPAYPGLDAVGQALDAGAKETGVTIHYVDAGMDTGTVIRQKTVSITTDDTKKSLGEKIKQAEHQLYPETLQQLFRKGF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP054706
EMBL· GenBank· DDBJ
QQK79320.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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