A0A7T6Z7U5 · A0A7T6Z7U5_9BACI

  • Protein
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • Gene
    metE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1135-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1185-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site432-434L-homocysteine (UniProtKB | ChEBI)
Binding site432-434L-methionine (UniProtKB | ChEBI)
Binding site485L-homocysteine (UniProtKB | ChEBI)
Binding site485L-methionine (UniProtKB | ChEBI)
Binding site5625-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site600L-homocysteine (UniProtKB | ChEBI)
Binding site600L-methionine (UniProtKB | ChEBI)
Binding site6065-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site642Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site642Zn2+ (UniProtKB | ChEBI); catalytic
Binding site644Zn2+ (UniProtKB | ChEBI); catalytic
Binding site644Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site666Zn2+ (UniProtKB | ChEBI); catalytic
Binding site666Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site695Proton donor
Binding site727Zn2+ (UniProtKB | ChEBI); catalytic
Binding site727Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • ORF names
      HUG15_22390

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC5-3
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Salicibibacter

Accessions

  • Primary accession
    A0A7T6Z7U5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-313Cobalamin-independent methionine synthase MetE N-terminal
Domain427-749Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    86,168
  • Last updated
    2021-09-29 v1
  • Checksum
    51A5CBB3959FEBAB
MRLKTSLLGYPRIGEKREWKKALEAHWAGNLSSEDLHAEMKHIRLNHLKKQQDAGIETIPVGDFTYYDHILDATAMFGLVPDRFEYDGGNVSLETYFAMARGNEDVPASEMTKWYNTNYHYIVPEIGNKTPTLTENYLLDAYKEAKEELGIEGKPVIIGPYSFLKLAKHYKNDAFPELLSQLTDVYVQLFQALNDEGVQWVQVDEPSLVTTIPEEDLPLILKTYETLQKEVPQLNVLLQTYFEAVGHYEKVIELPVAGIGLDFVHDQGKNLHALQTHGFPEDKVLGAGVIDGRNIWKAKLKDKLVLVKEIQKYVGDDKVWLQTSASLLHTPVTVENEPTLDETLKQALSFADEKMEELRTLQQLGLGESETNEKRLLEDNEEIFAALKTKGWRKEEPDTATSKGVGRPLSYEERRKKQLEKWPLPKLPTTTIGSFPQTRDVRRLRARLKKGELTRSEYQSAIQSHIKTWIDHQEEIGLDVLVHGEFERNDMVEYFGERLEGFAFTKNAWVQSYGSRGVKPPIIYGDVRFTEPMTVEETVYAQSLTDKPVKGMLTGPVTILNWSFERDDLPKQQVAFQIAEAIKEEVSALEDAGIEMIQIDEPALREGLPLKRENWSTYLEWAVQAFRLSSSHVENTTQIHTHMCYSEFQDIIDAISALDADVISIETSRSQGDILETFEDNVYDKGIGLGVYDIHSPRVPSEEEMLHIIRRALSVLPADLFWVNPDCGLKTRNEEETVAALKKMVNAAEKARAEVTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP054705
EMBL· GenBank· DDBJ
QQK78458.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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