A0A7T6Z7T9 · A0A7T6Z7T9_9BACI

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    ftsH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

169050100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site210-217ATP (UniProtKB | ChEBI)
Binding site432Zn2+ (UniProtKB | ChEBI); catalytic
Active site433
Binding site436Zn2+ (UniProtKB | ChEBI); catalytic
Binding site508Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      HUG20_00525

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC21-4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Salicibibacter

Accessions

  • Primary accession
    A0A7T6Z7T9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-26Helical
Transmembrane117-138Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain202-341AAA+ ATPase
Region615-690Disordered
Compositional bias632-668Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    690
  • Mass (Da)
    76,489
  • Last updated
    2021-09-29 v1
  • Checksum
    FB88756CDCBE4CA0
MNRTVRYTFFWLFVLLILIGIVQLFTDDPVEDEMMNTDEFMQALEQDEIASMTVQPEMEVYLIEGEMVNGGEEDEANEFTAHILRSPEVTDMLLDAMETNESLTAVDTEPGEEPGGWLQFLVAVIPFIIIFILFFFLLSQMQGGGNKMMNFGKSKAKMQQESDKKKARFKDVAGAEEEKQELVEIVDFLKDPRKFANIGARIPKGVLLVGPPGTGKTLLGRAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFNNAKNNAPCIIFIDELDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFEGNEGIIIIAATNRSDVLDPALLRPGRFDRQITVGLPDVRGREDVLKVHVREKPIDDDVELGAIAQRTPGFSGAELENLLNEAALVAARSNSVKIKMVHIEEAIDRVIAGPAKKTRVISEKEKNIVAHHEAGHTVVGVKLQNADAVHKVTIVPRGQAGGYAMMLPKEDRYFMTKPELLDKIVGLLGGRVSEDIIFGEASTGAHNDFQRATAIARKMVMEYGMSEKLGPLQFGSTGGGQVFLGRDIQNEQNYSDAIAHEIDKEVQKIIKDSYERCRQILTENKDKLELVAQNLLELETLDAEQIYSLVEEGKLPEGHHSNQTQEDALKNSGDVDPVDDENVKVNIGSQEEEQPETKNDQSKANEETEEQDQTEEQDNEEKQEDDNRRS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias632-668Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP054706
EMBL· GenBank· DDBJ
QQK78555.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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