A0A7T5UID9 · A0A7T5UID9_9BACT

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    ftsH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163150100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site192-199ATP (UniProtKB | ChEBI)
Binding site414Zn2+ (UniProtKB | ChEBI); catalytic
Active site415
Binding site418Zn2+ (UniProtKB | ChEBI); catalytic
Binding site492Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      HYS17_04090

Organism names

  • Taxonomic identifier
  • Strain
    • NC_groundwater_70_Ag_B-0.1um_54_66
  • Taxonomic lineage
    Bacteria > Bdellovibrionota > Bdellovibrionia > Bdellovibrionales > Pseudobdellovibrionaceae > Micavibrio

Accessions

  • Primary accession
    A0A7T5UID9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane97-119Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_503233713320-631ATP-dependent zinc metalloprotease FtsH

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain184-323AAA+ ATPase
Region603-631Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    631
  • Mass (Da)
    68,606
  • Last updated
    2021-09-29 v1
  • Checksum
    C2260A9D37B04FB7
MFWMAIGILLMFLFNVFQGTQTQKPGAGEMMAYSDFMAEAAGGRISDITIKGQDVTGHYTGTGKEFSVLVPDNENVVERLSGTGVRITAEPQDPEKISALGIFLSWFPMLLLIGVWIFFMRQMQSKGGGGALGFGKSRARMLTEANGRVTFEDVAGIEEAKVELQEIVEFLKDPQKFQRLGGKIPRGALLVGSPGTGKTLIARAVAGEANVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGVIILAATNRPDVLDPALLRPGRFDRQIVVPLPDVKGREKILQVHMKKVPLAKNVEPLVIARGTPGFSGADLANLVNEAALLAARRNKRVVGMEDFEEAKDKVMMGAERKSMVMSDNEKKLTAYHEAGHAVVAVHLEESDPVHKATIIPRGRALGMVMRLPEGDRVSMTRAKLKADLAVAMGGRLAEEIIFGYDKVTTGASSDISMATNMARRMVTEWGMSDKLGPLRYVSDQEEVFLGHSVTQSKNMSDETAKLVDAEVRVIVDEAYNKARDILTTYIDQLHNLAKALLEYETLTGDEIRGLLRGEPIIRVDDRLGSEDSKPKSSVPKTGGLGGGEVPQGV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP066681
EMBL· GenBank· DDBJ
QQG37360.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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