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A0A7T5E027 · A0A7T5E027_9CYAN

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site101-103substrate
Binding site132-135substrate; in site B
Binding site142-144substrate
Binding site190substrate
Active site191Proton donor/acceptor
Active site321
Binding site322substrate
Binding site327-329substrate
Site334Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      GFS31_02070

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BL0902
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Leptolyngbyales > Leptolyngbyaceae > Leptolyngbya group > Leptolyngbya

Accessions

  • Primary accession
    A0A7T5E027

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-345Fumarate lyase N-terminal
Domain411-464Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    465
  • Mass (Da)
    50,213
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    0475C484DCC107F67277A7FFB45BEFDD
MPEQPTTRQETDSMGAIAVPNDRYWGAQTQRSIRYFSIGQDHMPLAVVHAIATIKKASALANADLGKLPREKAQMIAQAADEILAGQLNDHFPLRVWMTGSGTQCNMNVNEVIANRAIERAGGELGSKTPIHPNDHVNMSQSSNDVFPAAMHIAAAQALHHSLIPSINRLRHALHEKANAWADIVKIGRTHMQDAVPLTLGQEFSGYVGMLDDNLARLESVLPELYPLALGGTAVGTGLNAGAGFAETAAQYIAQFTGMPFVTAPNKFTVMGAHDALVMTSGVLKTLAVSLYKIANDIRLLSCGPRAGFGELHLPENEPGSSIMPGKVNPTQCEALAMVAVQVMGYDAAVAFAGASGYLEMNVYKPLMIFNILQSARLMTDSSHNFTEFLVEGMTPNRKKISQYVDNSLMLVTALSPVIGYDKASQIAHHAFEHDLTLKDAALSLGYISAEDFDRAINPRRMTQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP046155
EMBL· GenBank· DDBJ
QQE63540.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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