A0A7T5BNL8 · A0A7T5BNL8_9FLAV
- ProteinGenome polyprotein
- GenePOLY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3390 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1524 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1548 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1608 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2546 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2576 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2577 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2594 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2595 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2621 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2622 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2708 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2927 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2931 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2936 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2939 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3202 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3218 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3337 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A7T5BNL8
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 46-69 | Helical | ||||
Sequence: LVMAFIAFLRFLAIPPTAGILARW | ||||||
Transmembrane | 722-746 | Helical | ||||
Sequence: YTALFSGVSWIMKIGIGVLLTWIGL | ||||||
Transmembrane | 752-771 | Helical | ||||
Sequence: SMSFSCIVIGIITLYLGAVV | ||||||
Transmembrane | 1157-1175 | Helical | ||||
Sequence: MIAGVLFTFVLLLSGQITW | ||||||
Transmembrane | 1195-1218 | Helical | ||||
Sequence: MGVTYLALIATFKIQPFLALGFFL | ||||||
Transmembrane | 1283-1304 | Helical | ||||
Sequence: IFTLTVAWRTATLILAGISLFP | ||||||
Transmembrane | 1316-1334 | Helical | ||||
Sequence: WLPMTVAAMGVPPLPLFIF | ||||||
Transmembrane | 1371-1388 | Helical | ||||
Sequence: MAGPLVAGGLLIACYVIT | ||||||
Transmembrane | 1437-1464 | Helical | ||||
Sequence: ILTVLLKTALLIVSGIFPYSIPATLLVW | ||||||
Transmembrane | 2147-2166 | Helical | ||||
Sequence: LLLLGLMILLTGGVMLFLIS | ||||||
Transmembrane | 2173-2190 | Helical | ||||
Sequence: TSIGLICVVASSGMLWMA | ||||||
Transmembrane | 2196-2213 | Helical | ||||
Sequence: WIASAIVLEFFMMVLLIP | ||||||
Transmembrane | 2225-2242 | Helical | ||||
Sequence: QLAYVVIGILTLAAIVAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 283↔310 | |||||
Sequence: CVGVGNRDFVEGLSGATWVDVVLEHGGC | ||||||
Disulfide bond | 340↔396 | |||||
Sequence: CIEGKITNVTTDSRCPTQGEAILPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTC | ||||||
Disulfide bond | 354↔385 | |||||
Sequence: CPTQGEAILPEEQDQNYVCKHTYVDRGWGNGC | ||||||
Disulfide bond | 372↔401 | |||||
Sequence: CKHTYVDRGWGNGCGLFGKGSLVTCAKFQC | ||||||
Disulfide bond | 463↔563 | |||||
Sequence: CSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWTSGAITETPTWNKKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGGTSIFAGHLKC | ||||||
Disulfide bond | 580↔611 | |||||
Sequence: CSNAFVLKKEVSETQHGTILIKVEYKGEDAPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1344-1473 | Flavivirus NS2B | ||||
Sequence: SWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGLLIACYVITGTSADLTVEKAADVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTVLLKTALLIVSGIFPYSIPATLLVWHTWQKQTQR | ||||||
Domain | 1474-1651 | Peptidase S7 | ||||
Sequence: SGVLWDVPSPPETQKAELEEGVYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTYNGKRLEPNWASVKKDLISYGGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTMPGIFQTTTGEIGAVALDFKPGTSGSPIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPE | ||||||
Domain | 1654-1810 | Helicase ATP-binding | ||||
Sequence: EEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFPQSNAPIQDEE | ||||||
Domain | 1820-1986 | Helicase C-terminal | ||||
Sequence: SGNDWITDFAGKTVWFVPSIKAGNDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPRRCLKPVILTDGPERVILAGPMPVTVASAAQRRGRVGRNPQKENDQYIFMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 2492-2753 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITRHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPIPMSTYGWNIVKLMSGKDVFYLPPERCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTYRRPTIEKDVDLGAGTRH | ||||||
Domain | 3017-3167 | RdRp catalytic | ||||
Sequence: GAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPKGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKTDLENPHLPEKKIIQWLETKGVERLKRMAISGDDCVVKPIDDRFANA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,390
- Mass (Da)378,453
- Last updated2021-06-02 v1
- Checksum5917BDA457476FEC