A0A7T4QXU7 · A0A7T4QXU7_9GAMM

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

120020406080100120140160180200
Type
IDPosition(s)Description
DNA binding28-48H-T-H motif
Site82-83Cleavage; by autolysis
Active site117For autocatalytic cleavage activity
Active site154For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • ORF names
      I6N98_10040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • csc3.9
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Cellvibrionales > Spongiibacteraceae > Spongiibacter

Accessions

  • Primary accession
    A0A7T4QXU7

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-65LexA repressor DNA-binding
Domain75-191Peptidase S24/S26A/S26B/S26C

Sequence similarities

Belongs to the peptidase S24 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,189
  • Last updated
    2021-09-29 v1
  • Checksum
    E1C3EB5EBC67BDBE
MEKLTARQNQVLELIKSHIEDTGYPPTRADIARELGFRSPNAAEEHLKALARKGAIEIIPGASRGIRLPENPGLPIIGRVAAGNPILAEANIEDYCDIAPSLFSPAADYFLRVRGDSMIEVGIFEDDLLAVHRTQDVRNGQIVVARIDDEVTVKRLQQQRSKYQVLLLPENKDYEPIEVDLRHQDFAIEGLSVGVLRCGS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP066167
EMBL· GenBank· DDBJ
QQD16736.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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