A0A7S9EXR0 · A0A7S9EXR0_9APIA

  • Protein
    DNA-directed RNA polymerase subunit alpha
  • Gene
    rpoA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Cellular Componentplastid
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionprotein dimerization activity
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit alpha
  • EC number
  • Short names
    RNAP subunit alpha
  • Alternative names
    • RNA polymerase subunit alpha
    • Transcriptase subunit alpha

Gene names

    • Name
      rpoA

Encoded on

  • Plastid

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Apiales > Apiaceae > Apioideae > Acronema clade > Meeboldia

Accessions

  • Primary accession
    A0A7S9EXR0

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-234Alpha N-terminal domain (alpha-NTD)
Domain29-233DNA-directed RNA polymerase RpoA/D/Rpb3-type
Region261-353Alpha C-terminal domain (alpha-CTD)

Domain

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

Sequence similarities

Belongs to the RNA polymerase alpha chain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    40,271
  • Last updated
    2021-06-02 v1
  • Checksum
    091C12954F36F5CF
MVREKVTVSTRTLQWKCVESKADNQRLYYGRFILSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSDKIPHEFSTLVGIQESVHDILMNLKEIVLRSNLYGTCDASICVRGPGNVTAQDIILPPYVEVVDNTQHIASLTEPIELCIGLQIERNRGYLIKTPNNNSQDGSYPIDAVFMPVRNANHSIHSYGNGNDKQEILFLEIWTNGSLTPKEALHEASRNLIDLFIPFLHTEEENLHLADNQHMVPLPPFTFHDKLYKLRKNKKKIALKSIFIDQSELPPRIYNCLKRSNIYKLLDLLNNSQEDLMKIEHFRIKDVKQILGILEKHFSFYLAKKPKMGFESLAQLIDSESG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT843765
EMBL· GenBank· DDBJ
QPG24194.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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