A0A7S8F0R4 · A0A7S8F0R4_PVMA

Function

function

Has helicase activity. It may be involved in replication.
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.

Catalytic activity

  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
    EC:3.4.22.45 (UniProtKB | ENZYME | Rhea)
  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
    EC:3.4.22.44 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

130592004006008001,0001,2001,4001,6001,8002,0002,2002,4002,6002,8003,000
TypeIDPosition(s)Description
Active site641For helper component proteinase activity
Active site714For helper component proteinase activity

GO annotations

AspectTerm
Cellular Componenthelical viral capsid
Cellular Componenthost cell cytoplasmic vesicle
Cellular Componenthost cell nucleus
Cellular Componentvesicle
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type peptidase activity
Molecular Functionstructural molecule activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

Accessions

  • Primary accession
    A0A7S8F0R4

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain154-298Peptidase S30
Domain633-755Peptidase C6
Domain1226-1378Helicase ATP-binding
Domain1397-1556Helicase C-terminal
Domain2032-2250Peptidase C4
Domain2516-2640RdRp catalytic
Region2797-2818Disordered
Compositional bias2801-2818Basic and acidic residues

Sequence similarities

Belongs to the potyviridae genome polyprotein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,059
  • Mass (Da)
    346,149
  • Last updated
    2021-06-02 v1
  • Checksum
    705258FC168C1383
MATQAIMVGEFKILEVNCKPHAPVAAIHVPTQTPKTNDIQWADLEFTLAKSLQRQAHGVVKVDKHGTARIKRASKHHMSCLEQQMADEVAEREAFMAAPTQLVTSIIFAGTTPPSMMETETIVKKIHTVGKHAKVMRKRSYITPPTDKSLRNHGVTPYSVQQLCRTLGNLSKRTGISLEVVGKTSKATKLQFTKTSFGYMARVHLKHHDGRMHRRDLVVDTSTTTIMQTLFLKTARTNANLDVLTHGSSGLVFWNYLVTGQRMRTRDNFIIVRGRCNGILVDARAKLSESTMLSTHHYSTGDVFWRGFNRTFLENKPINLDHVCSSDFSVEECGSIAALICQSLLPCGKITCRACAAKNLNMDEDTFKEFQTQRAREISAVIISKYPNFACVSQFIDRYFSHQRVLNPNVNAYREILKIVGGFTQSPYTHIQELNEILVLGGRATPEQLGSASAHLLEITRFVRNRTDNIKKGSLALFRNKISAKAHVNTALMCDNQLDRNGNLIWGERGYHAKRFFSNYFDIITPGGGYKQYIERRVPNGIRKLAIGNLIVTTNLEALREQLEGESIEKKAVTKACVSMSDNNYKYPCCCVTLDDGTPLYSTFIMPTKNHLVIGNSGDPKFLDLPTDISTQMYIAKSGYCYMNIFLAMLVNVDESDAKDFTKKVRDIIVPDLGEWPTLIDVATSCSLLSAFYPATSAAELPRILVDHDLKTMHVIDSYGSLNTGYHVLKANTVRQLIQFASNSLDSEMKHYRVGGTPNSQINGYATIKMLAKAVYRPKLMKEIIHEQPYMLVMSLMSPGILIALANSGALEMGIHHWIREGDSLVKMAHMLRTVAQNVSVARATWVQQEIISDSAQQMLETILNGTIPNVSYFQAIQYLTMLAASREVDAEVRVTGYYTFKLQTSELLEKTYLSLLEDSWQELSYFGRFQAIRHSRRHCTAGTIVVKPERHVDLGGIYATSYQFALAKQMEYSKKAVYQAVNGLQARFNNITNQIYCKILNWPKRLFPDLVKFINTMLAITVALQLYIAFATILRHHQQCKQDSLELEYCKKERQLITLYDFFIAKQPYATEEEFMAHVDEQNPDLSNFAREYCAEVVLFQAKASEQVNFERIIAFISLVLMMFDCERSDCVYRSLTKLKSLMSTVENTVQFQSLDDIGPTLEEKNMTIDFDLDTDTIVGKSIVGHTFKEWWDVQLNTNRIVPHYRTEGHFMEFTRANAPTIAHQISHDLHTDIMLRGAVGSGKSTGLPYHLSKKGTVLLLEPTRPLAENVTKQLKSDPFHVSPTLRMRGMAVFGSTPIHVMTTGFALHYLANNLKMLSTYDFIIIDEFHVHDSNAIALRNLLHEHNYQGKLIKVSATPPGREVEFSTQYPVEIRVEDQVSFQDFVKAQGNGSNLDLTSKCDNLLVYVASYNEVDQLSKLLLERHFLVTKVDGRSMKLGQVEIITKGNANKKHFIVATNIIENGVTLDIDAVIDFGMKVVPFLDSDNRMISYNKVSISYGERIQRLGRVGRNKAGVALRIGHTEKGISDVPVVIATQAAFLCFVYGLPISTQSVTTQVLSNVTLKQARTMVQFELPIFYMAHLVRYDGTMHPAIHNELKKYKLRDSEIQLSKLAIPSKCVPIWMTGKAYRLLTHNSQIPDAVRVPFLTKEVPDKLHENVWAIVEKFKCDAGIGRMTSAQASKVAYTLETDIHSIQRTILIIDQLLEREMQKQSHFEMVTNQSCSSGMLSLQTMMNAIQSRYAKNHTAGNIEILQRAKAQLLEFSNLSGDISTESALREFGYLEAVQFQSGTQVSNFLGLEGHWKKSLITKDLLIVGGVCVGAAWMIGEYFFKKSKEVVAFQGYNKRQRQKLKFARARDEKMGHYVEAPDSTLEHYFGSAYTKKGKTKGKTHGMGKKNHRFVNMYGFDPSDYTFIRYVDPLTGYTLDESPYTDIRLIQSQFSDIREQQLLNDELERNMVYHKPGVQGYLVKDKTSQILKIDLTPHIPLKVCDATNNIAGHPDREGELRQTGKGQLLDYAELPQKKELVEFESTSMFRGVRDYNPISSVICQLENESEGRTTQLFGLGFGPFIITNQHLFVRNNGSLTVRSQMGVFKVNSTVTLQMRPVEGRDVLIIKMPKDFPPFPQRLKFRQPTHSEKVCLILTNFQQKSSSSMVSETSHIIPKENTYFWKHWISTKEGHCGSPIVSTTDGAILGIHSLSNMTNTSNYFACFPKGFTETYLATESVHEWVKGWKFNASNVCWGSFHLQDSKPTKEFKTVKLVTDLLGEAVYTQGCDSKWLFNAAHTNIQAVAQLESNLVTKHTVKGKCKLFETYLNVDKAAHDFFSKYMGFYKPSKLNREAYTQDLMKYSKVIQVGEVDCGVFENALTGLLHNLGRWGFTTACYTTDEDSIYAALNMKSAVGALYRGKKRDYFDAMSPSEREHLLFLSCKRLYFGQLGVWNGSLKAELRPKEKVDLNKTRTFTAAPIETLLGGKVCVDDFNNMFYSLHLKAPWSVGMTKFYGTWNQLMCKLPDDWVYCDADGSQFDSSISPYMINAVLRIRLHFMEDWDIGSQMLQNLYTEIVYTPISTPDGTVVKKFKGNNSGQPSTVVDNTLLVVLAMHYALLKSGVPLEEQDSVCVYCVNGDDLLIAIRPDMEHKLDGFQTLFSELGLNYEFNSRSKDKKDLWFMSHKAIQYGEILIPKLEEERIVSILEWDRSHEPIHRLEAICASMVESWGYPELTHEIRRFYAWVLEQSPYNALATTGLAPYIAESALKTLYTNVHPTSTELEKYSIQFDEQMDEEDDMVYFQAGTLDAGETPAQKSDGRKKEGEGNSGKAVAVKDKDVDLGTAGTHSVPRLKSMTSKLTLPMLKGKSVVNLDHLLSYKPKQVDLSNARATHEQFQNWYDGVMASYELEESSMEIILNGFMVWCIENGTSPDINGVWTMMDDEEQVSYPLKPMLDHAKPSLRQIMRHFSALAEAYIEMRSREKPYMPRYGLQRNLRDQSLARYAFDFYEITATTPVRAKEAHLQMKAAALKNSNTNMFGLDGNVTTSEEDTERHTATDVNRNMHHLLGVKGV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias2801-2818Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT435485
EMBL· GenBank· DDBJ
QPC97632.1
EMBL· GenBank· DDBJ
Genomic RNA
MT435493
EMBL· GenBank· DDBJ
QPC97640.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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