A0A7S7YLI8 · A0A7S7YLI8_9CRUS
- ProteinNADH-ubiquinone oxidoreductase chain 4
- GeneND4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Molecular Function | ubiquinone binding | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Branchiopoda > Anostraca > Artemiidae > Artemia
Accessions
- Primary accessionA0A7S7YLI8
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | |||
Transmembrane | 32-50 | Helical | |||
Transmembrane | 56-78 | Helical | |||
Transmembrane | 85-105 | Helical | |||
Transmembrane | 125-143 | Helical | |||
Transmembrane | 155-176 | Helical | |||
Transmembrane | 188-206 | Helical | |||
Transmembrane | 213-235 | Helical | |||
Transmembrane | 241-262 | Helical | |||
Transmembrane | 269-288 | Helical | |||
Transmembrane | 308-337 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length377
- Mass (Da)42,885
- Last updated2021-06-02 v1
- ChecksumC1DE83484958703B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MN240408 EMBL· GenBank· DDBJ | QPB69782.1 EMBL· GenBank· DDBJ | Genomic DNA |