A0A7S5QHH5 · A0A7S5QHH5_9FLAV
- ProteinGenome polyprotein
- GenePOLY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3192 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A7S5QHH5
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-48 | Helical | ||||
Sequence: LVMAFIAFLRFLAIPPTAGILARW | ||||||
Transmembrane | 80-98 | Helical | ||||
Sequence: SVTMLLMLLPTALAFHLTT | ||||||
Transmembrane | 1137-1156 | Helical | ||||
Sequence: MLMTGTLAVFLLLIMGQLTW | ||||||
Transmembrane | 1176-1199 | Helical | ||||
Sequence: MGTTYLALMATFKMRPMFAVGLLF | ||||||
Transmembrane | 1328-1346 | Helical | ||||
Sequence: LNEGIMAIGIVSILLSSLL | ||||||
Transmembrane | 1352-1369 | Helical | ||||
Sequence: LAGPLIAGGMLIACYVIS | ||||||
Transmembrane | 1421-1448 | Helical | ||||
Sequence: ILLKATLLAVSGVYPMSIPATLFVWYFW | ||||||
Transmembrane | 2128-2147 | Helical | ||||
Sequence: LMLLALIAVLTGGVTLFFLS | ||||||
Transmembrane | 2154-2171 | Helical | ||||
Sequence: TSIGLLCVTASSALLWMA | ||||||
Transmembrane | 2177-2194 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 2206-2223 | Helical | ||||
Sequence: QLAYVVIGLLFMILTVAA |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1325-1454 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAIGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEQEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPMSIPATLFVWYFWQKKKQR | ||||||
Domain | 1455-1632 | Peptidase S7 | ||||
Sequence: SGVLWDTPSPPEVERAVLDDGIYRILQRGLLGRSQVGVGVFQDGVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRFQGSWNTGEEVQVIAVEPGKNPKNVQTTPGTFKTPEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPE | ||||||
Domain | 1635-1791 | Helicase ATP-binding | ||||
Sequence: DEVFKKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGREIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEE | ||||||
Domain | 1801-1967 | Helicase C-terminal | ||||
Sequence: SGYDWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNQNKEGDQYVYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 2999-3148 | RdRp catalytic | ||||
Sequence: GNMYADDTAGWDTRITEDDLQNEAKITDIMEPEHALLATSIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEVQLIRQMESEGIFLPSELETPNLAERALDWLEKHGAERLKRMAISGDDCVVKPIDDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length3,192
- Mass (Da)356,020
- Last updated2021-06-02 v1
- ChecksumA04156F2620302E2
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: R | ||||||
Non-terminal residue | 3192 | |||||
Sequence: G |