A0A7S1Q9I1 · A0A7S1Q9I1_ALECA

Function

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

147650100150200250300350400450
TypeIDPosition(s)Description
Binding site83Zn2+ (UniProtKB | ChEBI)
Binding site146Zn2+ (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase
    • Vitamin-B12 dependent methionine synthase

Gene names

    • ORF names
      ACAT0790_LOCUS19191

Organism names

Accessions

  • Primary accession
    A0A7S1Q9I1

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-161Hcy-binding
Domain194-455Pterin-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    476
  • Mass (Da)
    52,604
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    C646F3A85314A38C47C6DAF014587946
QVGGLVDGGVDLLMIETIFDTQNAKAAIFAVDEYFDRTKKERLPVMISATIVDNSGRTLSGQTIEAFFISIKHAKAFTVGINCALGAAQMKKFYKMLTDMNEGWCHVYPNAGLPNAMGGYDEDPEIFSTNILDYAKDGLLNFVGGCCGTFPSHIAAVANKVKGTAPRKLPELPKYPYMQLSGLEPCLLKPEAGFQLIGERCNLMGSAKFKKLVDAYKWDEAMEVCLAQCEKKADILDFNFDSDLIDGKSAMGKFMRLCVTEPNVARLPFMIDSSKWAVIEEGLKCVQGKCIVNSISLKVGEEEFLRQAKLCQRFGAAVVLMAFDEQGQAATFEDKVRICQRSYRLLRSKLDFNPEDVIFDCNVLTIATGLPEHNSYGIDFINAVAEIKRTCPCVSFSGGLSNLSFSFRGLNSLRDAMHSVFLYHAVPKGLNMSIVNPGGLPRYCDIDESSRKLCEEVILNKSADGNHVERFLEFAE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue476

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HBGE01031780
EMBL· GenBank· DDBJ
CAD9124954.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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