A0A7S0DQ90 · A0A7S0DQ90_9EUKA
- ProteinDNA-(apurinic or apyrimidinic site) endonuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids430 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 140 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 173 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 258 | ||||
Active site | 295 | Proton donor/acceptor | |||
Binding site | 295 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 297 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 297 | Transition state stabilizer | |||
Site | 370 | Important for catalytic activity | |||
Binding site | 416 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 417 | Proton acceptor | |||
Binding site | 417 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 417 | Interaction with DNA substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-(apurinic or apyrimidinic site) endonuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Rhizaria > Cercozoa > Chlorarachniophyceae > Amorphochlora
Accessions
- Primary accessionA0A7S0DQ90
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_5030739094 | 18-430 | DNA-(apurinic or apyrimidinic site) endonuclease | ||
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 51-82 | Basic and acidic residues | |||
Region | 51-118 | Disordered | |||
Compositional bias | 92-108 | Polar residues | |||
Domain | 137-417 | Endonuclease/exonuclease/phosphatase | |||
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length430
- Mass (Da)47,975
- Last updated2021-06-02 v1
- Checksum3EF375D7B8A03659
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 51-82 | Basic and acidic residues | |||
Compositional bias | 92-108 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HBEM01030920 EMBL· GenBank· DDBJ | CAD8462102.1 EMBL· GenBank· DDBJ | Transcribed RNA |