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A0A7R9QGS3 · A0A7R9QGS3_9ACAR

  • Protein
    Methylcytosine dioxygenase TET
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • ORF names
      OSB1V03_LOCUS20394

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Oribatida > Brachypylina > Oppioidea > Oppiidae > Medioppia

Accessions

  • Primary accession
    A0A7R9QGS3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain123-2372OGFeDO JBP1/TET oxygenase

Sequence similarities

Belongs to the TET family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    237
  • Mass (Da)
    26,934
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    47CCCB272E553F162B7D33BFC38DD8EE
MGLYGRAVRIEIVVYMEKEGKSREGCPIAKSVLRRANDQELVLALVRYRKGHKCSQTYIIVSIVVWDAIDRCFADKLYDIIVYKVNEYGISTQRRCAQNDSKTCGCQGVNERTRGACYSFGCSWSMFRDGCKFRDSQRHNVRKFRLKKRNQEYELEYHLDKLATGLAPLYEAIAPDAYYNQITFESDGSDCRIGDGIGRPFSGVTACLDFCAHSHKDLHNMNNGCTVVVTLGKYRGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue237

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OC888069
EMBL· GenBank· DDBJ
CAD7645205.1
EMBL· GenBank· DDBJ
Genomic DNA
CAJPIZ010033494
EMBL· GenBank· DDBJ
CAG2120447.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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