A0A7R9GSJ4 · A0A7R9GSJ4_TIMPO

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processbrassinosteroid biosynthetic process
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      TPSB3V08_LOCUS605

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Phasmatodea > Timematodea > Timematoidea > Timematidae > Timema

Accessions

  • Primary accession
    A0A7R9GSJ4

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane71-88Helical
Transmembrane108-128Helical
Transmembrane149-174Helical
Transmembrane180-197Helical
Transmembrane238-257Helical
Transmembrane263-280Helical
Transmembrane301-324Helical
Transmembrane330-350Helical
Transmembrane420-438Helical

Keywords

  • Cellular component

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    472
  • Mass (Da)
    53,589
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    400A98A2BAAF45876BD4D66060C4094C
MHGCIYRLGHSSIRWLHLTRAHPTDTLLAAGNFCTPSDMQLVVHVRTYNRVRIATMAGGWYAVLRYHVTPPLFLVFFPGVVNFMALWGQGERDVTWGLAASKALGNSFSWAAVGVLVMWASVWLHVPARATLGPPTKFGYRPPYKDNGVLYYWVSLTAFFILEALFPGLSTALFLNMPELLGSLNVSALLLCGLLFVKGRYLPDHPQDKQPSRPVLYEFFTGLELHPRLLGMDVKQLTNCRVGLMAWQLLIIAFYIAGVERHGFNIAALVNLLLQSMYLAKFFWWEYGYFNTLDIILDRAGYYICWGCLVWVPCLYTFSSYYLVAHPPQISNLAAVGAALLGVATTLLNYRVDYEKQVFRSAPDGKCVLWGKPARYIVANLVSSPGKSRKLLVSGFWGVARHLNYTFELVATLAWCLPGWGLGLWPFLYFYFLVALLVHRTFRDEEKCSAQYGDSWELYCKEVPYRLVPYVF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OD000189
EMBL· GenBank· DDBJ
CAD7396296.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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