A0A7R9GSJ4 · A0A7R9GSJ4_TIMPO
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids472 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | sterol biosynthetic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Phasmatodea > Timematodea > Timematoidea > Timematidae > Timema
Accessions
- Primary accessionA0A7R9GSJ4
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 71-88 | Helical | |||
Transmembrane | 108-128 | Helical | |||
Transmembrane | 149-174 | Helical | |||
Transmembrane | 180-197 | Helical | |||
Transmembrane | 238-257 | Helical | |||
Transmembrane | 263-280 | Helical | |||
Transmembrane | 301-324 | Helical | |||
Transmembrane | 330-350 | Helical | |||
Transmembrane | 420-438 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length472
- Mass (Da)53,589
- Last updated2021-06-02 v1
- MD5 Checksum400A98A2BAAF45876BD4D66060C4094C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
OD000189 EMBL· GenBank· DDBJ | CAD7396296.1 EMBL· GenBank· DDBJ | Genomic DNA |