A0A7R9ASP4 · A0A7R9ASP4_TIMSH
- ProteinN(6)-L-threonylcarbamoyladenine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids496 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Catalytic activity
- L-threonylcarbamoyladenylate + adenosine37 in tRNA = N6-L-threonylcarbamoyladenosine37 in tRNA + AMP + H+
Cofactor
Note: Binds 1 divalent metal cation per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | acyltransferase activity, transferring groups other than amino-acyl groups | |
Molecular Function | metal ion binding | |
Biological Process | tRNA threonylcarbamoyladenosine modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN(6)-L-threonylcarbamoyladenine synthase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Phasmatodea > Timematodea > Timematoidea > Timematidae > Timema
Accessions
- Primary accessionA0A7R9ASP4
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5030873749 | 21-496 | N6-L-threonylcarbamoyladenine synthase | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)54,586
- Last updated2021-06-02 v1
- MD5 Checksum6D4DB53F41B7E8891357FBC6D6FAF556
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
OC001161 EMBL· GenBank· DDBJ | CAD7259267.1 EMBL· GenBank· DDBJ | Genomic DNA |