A0A7R8GUQ3 · A0A7R8GUQ3_MOUSE

  • Protein
    Interleukin family protein
  • Gene
    Il10
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Immune regulatory cytokine.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functioninterleukin-10 receptor binding
Molecular Functionprotein dimerization activity
Biological Processcellular response to estradiol stimulus
Biological Processcellular response to lipopolysaccharide
Biological Processimmune response
Biological Processliver regeneration
Biological Processnegative regulation of autophagy
Biological Processnegative regulation of B cell proliferation
Biological Processnegative regulation of cytokine production involved in immune response
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of membrane protein ectodomain proteolysis
Biological Processnegative regulation of MHC class II biosynthetic process
Biological Processnegative regulation of neuron apoptotic process
Biological Processnegative regulation of nitric oxide biosynthetic process
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpositive regulation of B cell apoptotic process
Biological Processpositive regulation of cytokine production
Biological Processpositive regulation of immunoglobulin production
Biological Processpositive regulation of macrophage activation
Biological Processpositive regulation of miRNA transcription
Biological Processpositive regulation of plasma cell differentiation
Biological Processpositive regulation of receptor signaling pathway via JAK-STAT
Biological Processregulation of synapse organization
Biological Processresponse to activity
Biological Processresponse to carbon monoxide
Biological Processresponse to glucocorticoid
Biological Processresponse to inactivity
Biological Processresponse to insulin
Biological Processresponse to xenobiotic stimulus

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin family protein

Gene names

    • Name
      Il10
    • Synonyms
      If2a

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A7R8GUQ3

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_503159572122-178Interleukin family protein
Disulfide bond30↔126
Disulfide bond80↔132

Keywords

Interaction

Subunit

Homodimer. Interacts with IL10RA and IL10RB.

Family & Domains

Sequence similarities

Belongs to the IL-10 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    178
  • Mass (Da)
    20,641
  • Last updated
    2021-06-02 v1
  • Checksum
    9A283E6FFC99312B
MPGSALLCCLLLLTGMRISRGQYSREDNNCTHFPVGQSHMLLELRTAFSQVKTFFQTKDQLDNILLTDSLMQDFKGYLGCQALSEMIQFYLVEVMPQAEKHGPEIKEHLNSLGEKLKTLRMRLRRCHRFLPCENKSKAVEQVKSDFNKLQDQGVYKAMNEFDIFINCIEAYMMIKMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR761010
EMBL· GenBank· DDBJ
CAB0000172.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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