These data suggest that increased IFN-alpha8 activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7.
Not Associated with INFECTION: respiratory syncytial virus bronchiolitis., Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Data describe the species specificity of IFN-alphas the residues in murine IFN-alpha4 that preclude strong affinity interactions with human IFNAR1 and 2 and residues in human IFN-alpha8 that resemble a receptor interactive domain in murine IFN-alpha4.
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