A0A7R7ZPS7 · A0A7R7ZPS7_ASPCH

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site70-75FMN (UniProtKB | ChEBI)
Binding site121-124FMN (UniProtKB | ChEBI)
Binding site167-176FMN (UniProtKB | ChEBI)
Binding site202FMN (UniProtKB | ChEBI)
Binding site294NADP+ (UniProtKB | ChEBI)
Binding site449-452FAD (UniProtKB | ChEBI)
Binding site467-469FAD (UniProtKB | ChEBI)
Binding site484-487FAD (UniProtKB | ChEBI)
Binding site550NADP+ (UniProtKB | ChEBI)
Binding site612-613NADP+ (UniProtKB | ChEBI)
Binding site618-622NADP+ (UniProtKB | ChEBI)
Binding site654NADP+ (UniProtKB | ChEBI)
Binding site692FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      NCP1
    • Synonyms
      cprA
    • ORF names
      ACHE_60161A

Organism names

  • Taxonomic identifier
  • Strain
    • M1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Aspergillus

Accessions

  • Primary accession
    A0A7R7ZPS7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Cell membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain64-219Flavodoxin-like
Domain275-536FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    693
  • Mass (Da)
    76,177
  • Last updated
    2021-06-02 v1
  • Checksum
    FB570F118C05EBB9
MAQLDILDVAVLVVLLVGSVAYFTKGTYWAVPKTSAATPATNGVAKPGKTRNIVEKMDETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADLEDYDYDQLDTFGEDKIAFFVLATYGEGEPTDNAADFYQFVTSDDVAFESGASADDKPLSSMKFVAFGLGNNTYEHYNAMVRHIDTALTKLGAQRIGAAGEGDDGAGTMEEDFLAWKEPMWAALSESMTLEERDAVYEPVFSVSEEDSASPDDENVYLGEPTQGHLEGQPKGPFSPHNPFIAPIVESRELFNVKDRNCLHMEISIAGSGLNYQTGDHIAVWPTNAGIEVDRFLQVFGVDDKRHTVINIKGLDVTAKVPIPTPTTYDAAVRYYLEICAPVSRQFIATLAAFAPDEEIKAEIVRLGSDKDYFHEKITDKCYNIAQALQSLTSKPFTAVPFSLIIEGINKLQPRYYSISSSSMVQKDKISITAVVESTQLPGASHIVKGVTTNYLLALKQKQNGDPSPDPHGLTYDITGPRNKYDGIHVPVHVRHSNFKLPSDPAKPIIMVGPGTGVAPFRGFIQERAALAAKGQNVGTTVLFFGCRKSDEDFLYNDEFKTYQNQLGDSLKIVTAFSREGAQKVYVQHRLREHATLVSDLLKQKANFYVCGDAANMAREVNLVLGQIIAEHRGFGPERGEEMVKHMRSSGSYQEDVWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024421
EMBL· GenBank· DDBJ
BCR90275.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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