A0A7R7WA74 · A0A7R7WA74_ASPKA

Function

function

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide.
    EC:3.4.14.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

163550100150200250300350400450500550600
Type
IDPosition(s)Description
Active site312Charge relay system
Active site316Charge relay system
Active site528Charge relay system
Binding site572Ca2+ (UniProtKB | ChEBI)
Binding site573Ca2+ (UniProtKB | ChEBI)
Binding site607Ca2+ (UniProtKB | ChEBI)
Binding site609Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tripeptidyl-peptidase II
  • EC number

Gene names

    • Name
      SED2
    • ORF names
      AKAW2_40930A

Organism names

Accessions

  • Primary accession
    A0A7R7WA74

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_503055492827-635tripeptidyl-peptidase II

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain236-629Peptidase S53
Region334-353Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    635
  • Mass (Da)
    68,377
  • Last updated
    2021-06-02 v1
  • Checksum
    FFD1A441471E86AE
MLSSFLSQGAAVSLALLSLLPSPVAAEIFEKLSGVPNGELQTSIPQTGPYTNAFLRLLPGWRYANNPHGNEVIRLQIALQQHDVAGFEQAVMDMSTPGHADYGKHFRTHDEMKRMLLPSDTAVDSVRDWLESAGVHNIQVDADWVKFHTTVNKANALLDADFKWYVSEAKHIRRLRTLQYSIPDALVSHINMIQPTTRFGQIQPNRATMRSKPKHADETFLTAATLAQNTSHCDSIITPHCLKQLYNIGDYQADPKSGSKVGFASYLEEYARYADLERFEQHLAPNAIGQNFSVVQFNGGLNDQLSLSDSGEANLDLQYILGVSAPVPVTEYSTGGRGELVPDLSSPDPNDNSNEPYLDFLQGILKLDNSDLPQVISTSYGEDEQTIPVPYARTVCNLYAQLGSRGVSVIFSSGDSGVGAACLTNDGTNRTHFPPQFPASCPWVTSVGATSKTSPEQAVSFSSGGFSDLWPRPSYQQAAVQTYLTQHLGNKFSGLFNASGRAFPDVAAQGVNYAVYDKGMLGQFDGTSCSAPTFSGVIALLNDARLRAGLPVMGFLNPFLYGVGSESGALNDIVNGGSLGCDGRNRFGGTPNGSPVVPFASWNATTGWDPVSGLGTPDFAKLRGVALGEAKAYGN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024428
EMBL· GenBank· DDBJ
BCR99247.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help