A0A7R7VSA2 · A0A7R7VSA2_ASPCH

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      ACHE_51060A

Organism names

  • Taxonomic identifier
  • Strain
    • M1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Aspergillus

Accessions

  • Primary accession
    A0A7R7VSA2

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-26Helical
Transmembrane46-68Helical
Transmembrane80-100Helical
Transmembrane106-126Helical
Transmembrane138-160Helical
Transmembrane172-193Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-275Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    29,751
  • Last updated
    2021-06-02 v1
  • Checksum
    1350E85D6BBD414F
MARAFGGYWCVLTAVCTLMWGVYFIYDLPASLSTPLQAHLGLSDSKYAYLVSALYTAYATPNTILPFFCGPLVQRFGEKFALLLTLTSVVFGQLVFALSVQTQFQPGMILGRTLFGLGGEVMGVLGSEITTRWFRDKCLSLALAMNLASWRLGSVTNSILIPRLAKAHGVVAAGWMGTGFSLGVSILSALYLISIDDSTGGKRTGTEESNDEEEETGMNVNLLVSLAQCPRIFWQLGLLCMLGYGSINTFTNSAQRFLAFTFYGGDQRAAGSATR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024420
EMBL· GenBank· DDBJ
BCR89862.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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