A0A7R7E0K9 · A0A7R7E0K9_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3401 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus
Accessions
- Primary accessionA0A7R7E0K9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 709-734 | Helical | ||||
Sequence: VFHMVFGGTGFLSRILIGALLIWLGL | ||||||
Transmembrane | 741-761 | Helical | ||||
Sequence: LSLSFIGIGGMIVSLALGVGA | ||||||
Transmembrane | 1120-1138 | Helical | ||||
Sequence: ILGWPFGLVAAMMFLQIAI | ||||||
Transmembrane | 1150-1178 | Helical | ||||
Sequence: WLGLVALFGIVSGIFTFEDLVRVILAIGI | ||||||
Transmembrane | 1190-1209 | Helical | ||||
Sequence: AALVLEAVLAVRPGLLLAFV | ||||||
Transmembrane | 1221-1238 | Helical | ||||
Sequence: ATLLALSFVQQFLGGYGI | ||||||
Transmembrane | 1244-1270 | Helical | ||||
Sequence: AMGLVGLMLAAMVQATSFHTGLCIMAL | ||||||
Transmembrane | 1277-1294 | Helical | ||||
Sequence: VVTQAVQLLAVSLAIGQV | ||||||
Transmembrane | 1306-1331 | Helical | ||||
Sequence: AGLTAYVAGVGRFVPGFSTGMAFLVY | ||||||
Transmembrane | 1343-1363 | Helical | ||||
Sequence: AALGDGMACLGVLIMGLKVAM | ||||||
Transmembrane | 1369-1387 | Helical | ||||
Sequence: LPLVPVVGGVFVVMVAASL | ||||||
Transmembrane | 1441-1467 | Helical | ||||
Sequence: VLLGLTAMAGGIHWGLAACGVVAWLGW | ||||||
Transmembrane | 2148-2168 | Helical | ||||
Sequence: LLTLVSITLLLTGGLALVAAF | ||||||
Transmembrane | 2175-2192 | Helical | ||||
Sequence: MGVAALSVAVTAVLMYWG | ||||||
Transmembrane | 2198-2216 | Helical | ||||
Sequence: AMAGMVMTSTVFFLVVVPE | ||||||
Transmembrane | 2228-2250 | Helical | ||||
Sequence: LAYVIIGIAGVVGLVYCNEMGLL | ||||||
Transmembrane | 2283-2301 | Helical | ||||
Sequence: AVTWGIYAGVVSVVTPWLL | ||||||
Transmembrane | 2308-2330 | Helical | ||||
Sequence: GAVAAAGVASAGATSLAVLSSGI | ||||||
Transmembrane | 2350-2373 | Helical | ||||
Sequence: MSFSTALAASVCCLVHWSIVIPGA | ||||||
Transmembrane | 2417-2435 | Helical | ||||
Sequence: FAGWIMVALCVVSVVLDAS |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1342-1473 | Flavivirus NS2B | ||||
Sequence: RAALGDGMACLGVLIMGLKVAMGGSDSLPLVPVVGGVFVVMVAASLGTEGYMHIEKVGETRWDAQAVIRGSTLNRAVRRDRNGFMHVCDEERHDDVWQMVLLGLTAMAGGIHWGLAACGVVAWLGWNMLPRP | ||||||
Domain | 1474-1659 | Peptidase S7 | ||||
Sequence: GNRRADLVGPGPRRTLGEQRTSPLEDGVYRILAPGRLWGHRQAGAGVVIEGVLHTMFHVTHGAVLSTDDGYLIPGYADPERDLVTYAGPWKIAAKWKSGERVQLIAASPGRPVQNIDTLPGEFTLVTGEILGAVNIDCPPGTSGSPILNEDGVVVGLYGNGVIVDDGQYVSAISTTDPTDSSILDW | ||||||
Domain | 1665-1820 | Helicase ATP-binding | ||||
Sequence: ATWMKAGSVKIVQAAPGSGKTRVLLPRMIAELKAKRKRTLVLAPTRVVLDEMCQALKGVSKRVTTRGELKESGDGLITLMCHATFSHLMLTPMARKNFEVVIMDEAHFLDPGSIAARAYWEGMAKMGMSAFVMMSATPPGEHLQAFPPAVGTINDR | ||||||
Domain | 1830-2001 | Helicase C-terminal | ||||
Sequence: AGHEWITEYEGRTAWFVPSATAAARLAQVLIRHGKRVLCLSRSNFEKVNPQVRRGEFDFVLTTDIAEMGANLGVTRVIDPRLTRKPLARDDGIVMSGSIHVPTASAVQRRGRVGRAPHAVGEYVYQNQPDDDIREWACWTEAQMLLDNFQTPRSVAVGFCAAEAKYQPEAVG | ||||||
Domain | 2500-2764 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: AGHMGPTLGEVWKKRLNAMSKHRFYEYKTAGIVEVNRTEAREALKRGLTDHGHPVSRGAAKLHWLVERGFLEPKGWVTDLGCGRGGWSQYTATLPQVTRVVGYTLGTGGHEKPIPTESYGHNIITYHDKVDVMRLPTHLCDTVLCDIGESSSNVDVEAGRTIAVIEMFANWLEANPGAQFCCKVLCPYHPDVLAALEILVREHGGGLVRVPLSRNSTHEMYWVSGVKNKPTRAVNELSSFLLGRMAKNHEKEIIEEVWLGTGVRH | ||||||
Domain | 3028-3177 | RdRp catalytic | ||||
Sequence: VGYVADDTAGWDTRVSNADLEDEEQLLRWLSPTHRALAEPIMKMAYHNKVALVSRRANDGTLVTDVISRRDQRGSGQVVTYALNTWTNIKVQLLRMAEAEGILGDNLLHQARVLPLRNWLARHGEERMSRMAISGDDCVVRPPSEEFAFA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,401
- Mass (Da)373,946
- Last updated2021-06-02 v1
- Checksum46AA003913D66C09