A0A7R6PBU7 · A0A7R6PBU7_9GAMM
- ProteinUroporphyrinogen decarboxylase
- GenehemE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids347 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Catalytic activity
- uroporphyrinogen III + 4 H+ = coproporphyrinogen III + 4 CO2
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 23-27 | substrate | |||
Binding site | 73 | substrate | |||
Site | 73 | Transition state stabilizer | |||
Binding site | 150 | substrate | |||
Binding site | 205 | substrate | |||
Binding site | 323 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | uroporphyrinogen decarboxylase activity | |
Biological Process | protoporphyrinogen IX biosynthetic process from glutamate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUroporphyrinogen decarboxylase
- EC number
- Short namesUPD ; URO-D
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria
Accessions
- Primary accessionA0A7R6PBU7
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-27 | Uroporphyrinogen decarboxylase (URO-D) | |||
Domain | 138-154 | Uroporphyrinogen decarboxylase (URO-D) | |||
Sequence similarities
Belongs to the uroporphyrinogen decarboxylase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)38,495
- Last updated2021-09-29 v1
- ChecksumF9CEF3A085F26BEE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012977 EMBL· GenBank· DDBJ | BBB23322.1 EMBL· GenBank· DDBJ | Genomic DNA |