A0A7P0Z4D0 · A0A7P0Z4D0_HUMAN
- Protein2'-5' oligoadenylate synthase
- GeneOAS3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1062 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | defense response to virus | |
Biological Process | innate immune response |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2'-5' oligoadenylate synthase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7P0Z4D0
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,145 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 365 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 369 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 381 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 767 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 161-341 | 2'-5'-oligoadenylate synthetase 1 | ||||
Sequence: KPKPQVYSTLLNSGCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWK | ||||||
Domain | 535-719 | 2'-5'-oligoadenylate synthetase 1 | ||||
Sequence: KPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEAAALGMQACFLSRDGTSVQPWDVMP | ||||||
Domain | 755-845 | Polymerase nucleotidyl transferase | ||||
Sequence: ICSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVSKWENPRV | ||||||
Domain | 879-1060 | 2'-5'-oligoadenylate synthetase 1 | ||||
Sequence: RPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQPWPVKA |
Sequence similarities
Belongs to the 2-5A synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,062
- Mass (Da)118,327
- Last updated2021-06-02 v1
- Checksum2D4AB499285BB552
Computationally mapped potential isoform sequences
There are 23 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9Y6K5 | OAS3_HUMAN | OAS3 | 1087 | ||
F8VWK9 | F8VWK9_HUMAN | OAS3 | 177 | ||
A0A7P0T9J0 | A0A7P0T9J0_HUMAN | OAS3 | 1089 | ||
A0A7P0T9W6 | A0A7P0T9W6_HUMAN | OAS3 | 1061 | ||
A0A7P0T9Z5 | A0A7P0T9Z5_HUMAN | OAS3 | 219 | ||
F8VS35 | F8VS35_HUMAN | OAS3 | 223 | ||
A0A7P0T8J8 | A0A7P0T8J8_HUMAN | OAS3 | 577 | ||
A0A7P0T8S7 | A0A7P0T8S7_HUMAN | OAS3 | 1036 | ||
A0A7P0T7V2 | A0A7P0T7V2_HUMAN | OAS3 | 846 | ||
A0A7P0T884 | A0A7P0T884_HUMAN | OAS3 | 151 | ||
A0A7P0TAV3 | A0A7P0TAV3_HUMAN | OAS3 | 589 | ||
A0A7P0TB72 | A0A7P0TB72_HUMAN | OAS3 | 114 | ||
A0A7P0TB73 | A0A7P0TB73_HUMAN | OAS3 | 771 | ||
A0A7P0TAT5 | A0A7P0TAT5_HUMAN | OAS3 | 182 | ||
A0A7P0TAU8 | A0A7P0TAU8_HUMAN | OAS3 | 1130 | ||
A0A7P0TA44 | A0A7P0TA44_HUMAN | OAS3 | 172 | ||
A0A7P0TA50 | A0A7P0TA50_HUMAN | OAS3 | 567 | ||
A0A7P0TAC0 | A0A7P0TAC0_HUMAN | OAS3 | 971 | ||
A0A7P0TAC8 | A0A7P0TAC8_HUMAN | OAS3 | 723 | ||
A0A7P0TAS0 | A0A7P0TAS0_HUMAN | OAS3 | 724 | ||
A0A7P0Z4Q3 | A0A7P0Z4Q3_HUMAN | OAS3 | 97 | ||
A0A7P0Z4F1 | A0A7P0Z4F1_HUMAN | OAS3 | 1120 | ||
A0A7P0Z4F5 | A0A7P0Z4F5_HUMAN | OAS3 | 928 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC004551 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455724 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |