A0A7P0TB19 · A0A7P0TB19_HUMAN
- ProteinRING-type E3 ubiquitin transferase
- GenePPIL2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids614 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Molecular Function | peptidyl-prolyl cis-trans isomerase activity | |
Molecular Function | ubiquitin-protein transferase activity | |
Biological Process | protein folding | |
Biological Process | protein ubiquitination |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRING-type E3 ubiquitin transferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7P0TB19
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 552 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-108 | U-box | ||||
Sequence: RRLPFDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFT | ||||||
Domain | 285-433 | PPIase cyclophilin-type | ||||
Sequence: HTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTV | ||||||
Region | 457-478 | Disordered | ||||
Sequence: PETKVKSSQPQAGSQGPQTFRQ | ||||||
Region | 489-508 | Disordered | ||||
Sequence: TKRAAEEEPSTSATVPMSKK |
Sequence similarities
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length614
- Mass (Da)68,795
- Last updated2021-06-02 v1
- ChecksumC3D37E4BC6E56736
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13356 | PPIL2_HUMAN | PPIL2 | 520 | ||
F8WC56 | F8WC56_HUMAN | PPIL2 | 41 | ||
A0A7P0T8E8 | A0A7P0T8E8_HUMAN | PPIL2 | 573 | ||
A0A7P0T8P6 | A0A7P0T8P6_HUMAN | PPIL2 | 101 | ||
A0A7P0T9A5 | A0A7P0T9A5_HUMAN | PPIL2 | 43 | ||
A0A7P0T843 | A0A7P0T843_HUMAN | PPIL2 | 510 | ||
A0A7P0T839 | A0A7P0T839_HUMAN | PPIL2 | 305 | ||
A0A7P0T896 | A0A7P0T896_HUMAN | PPIL2 | 250 | ||
C9JDF0 | C9JDF0_HUMAN | PPIL2 | 160 | ||
A0A7P0TBL3 | A0A7P0TBL3_HUMAN | PPIL2 | 415 | ||
A0A7P0TAH4 | A0A7P0TAH4_HUMAN | PPIL2 | 342 | ||
A0A7P0TA15 | A0A7P0TA15_HUMAN | PPIL2 | 549 | ||
A0A7P0Z4K4 | A0A7P0Z4K4_HUMAN | PPIL2 | 499 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP000553 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |