A0A7P0TAW3 · A0A7P0TAW3_HUMAN

  • Protein
    Transitional endoplasmic reticulum ATPase
  • Gene
    VCP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentnucleoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionlipid binding
Molecular Functionprotein-containing complex binding
Biological Processautophagy
Biological Processcellular response to stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transitional endoplasmic reticulum ATPase
  • EC number
  • Alternative names
    • 15S Mg(2+)-ATPase p97 subunit
    • Valosin-containing protein

Gene names

    • Name
      VCP

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7P0TAW3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 346 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)3PRIDEPhosphoserine
Modified residue (large scale data)7PRIDEPhosphoserine
Modified residue (large scale data)13PRIDEPhosphoserine
Modified residue (large scale data)37PRIDEPhosphoserine
Modified residue (large scale data)197PRIDEPhosphoserine
Modified residue (large scale data)282PRIDEPhosphoserine
Modified residue (large scale data)284PRIDEPhosphoserine
Modified residue (large scale data)326PRIDEPhosphoserine
Modified residue (large scale data)352PRIDEPhosphoserine
Modified residue (large scale data)416PRIDEPhosphoserine
Modified residue (large scale data)702PRIDEPhosphoserine
Modified residue (large scale data)705PRIDEPhosphoserine
Modified residue (large scale data)765PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

    • ENSG00000165280Expressed in stromal cell of endometrium and 210 other cell types or tissues

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain25-108CDC48 N-terminal subdomain
Domain125-191CDC48
Domain237-373AAA+ ATPase
Domain510-649AAA+ ATPase
Region708-727Disordered

Sequence similarities

Belongs to the AAA ATPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    772
  • Mass (Da)
    86,119
  • Last updated
    2021-06-02 v1
  • Checksum
    396605497BEA6E10
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFR

Computationally mapped potential isoform sequences

There are 21 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P55072TERA_HUMANVCP806
C9JUP7C9JUP7_HUMANVCP761
A0A7P0T9X5A0A7P0T9X5_HUMANVCP110
A0A7P0T8D3A0A7P0T8D3_HUMANVCP47
A0A7P0T8D6A0A7P0T8D6_HUMANVCP50
A0A7P0T8Q4A0A7P0T8Q4_HUMANVCP77
A0A7P0T8Q5A0A7P0T8Q5_HUMANVCP754
A0A7P0T946A0A7P0T946_HUMANVCP77
A0A7P0T971A0A7P0T971_HUMANVCP55
A0A7P0T8A3A0A7P0T8A3_HUMANVCP760
A0A7P0TAY0A0A7P0TAY0_HUMANVCP237
A0A7P0TBF1A0A7P0TBF1_HUMANVCP56
A0A7P0TBK7A0A7P0TBK7_HUMANVCP107
A0A7P0TAQ1A0A7P0TAQ1_HUMANVCP733
A0A7P0TA22A0A7P0TA22_HUMANVCP76
A0A7P0Z4C6A0A7P0Z4C6_HUMANVCP694
A0A7P0Z4D1A0A7P0Z4D1_HUMANVCP102
A0A7I2YQJ0A0A7I2YQJ0_HUMANVCP43
A0A7I2V2Y2A0A7I2V2Y2_HUMANVCP458
A0A7I2V540A0A7I2V540_HUMANVCP804
A0A7I2V5G8A0A7I2V5G8_HUMANVCP334

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL353795
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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