A0A7P0T917 · A0A7P0T917_HUMAN

  • Protein
    Endoplasmin
  • Gene
    HSP90B1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Features

Showing features for binding site.

1719100200300400500600700
TypeIDPosition(s)Description
Binding site19ATP (UniProtKB | ChEBI)
Binding site23ATP (UniProtKB | ChEBI)
Binding site65ATP (UniProtKB | ChEBI)
Binding site70ATP (UniProtKB | ChEBI)
Binding site78ATP (UniProtKB | ChEBI)
Binding site84ATP (UniProtKB | ChEBI)
Binding site85-86ATP (UniProtKB | ChEBI)
Binding site110-115ATP (UniProtKB | ChEBI)
Binding site161ATP (UniProtKB | ChEBI)
Binding site364ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmelanosome
Cellular Componentsarcoplasmic reticulum lumen
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionunfolded protein binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endoplasmin
  • Alternative names
    • 94 kDa glucose-regulated protein
    • Heat shock protein 90 kDa beta member 1

Gene names

    • Name
      HSP90B1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7P0T917

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 499 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)22PRIDEPhosphoserine
Modified residue (large scale data)25PRIDEPhosphoserine
Modified residue (large scale data)71PRIDEPhosphothreonine
Modified residue (large scale data)85PRIDEPhosphoserine
Modified residue (large scale data)88PRIDEPhosphoserine
Modified residue (large scale data)222PRIDEPhosphoserine
Modified residue (large scale data)319PRIDEPhosphoserine
Modified residue (large scale data)355PRIDEPhosphoserine
Modified residue (large scale data)363PRIDEPhosphoserine
Modified residue (large scale data)417PRIDEPhosphoserine
Modified residue (large scale data)420PRIDEPhosphothreonine
Modified residue (large scale data)593PRIDEPhosphotyrosine
Modified residue (large scale data)641PRIDEPhosphoserine
Modified residue (large scale data)702PRIDEPhosphothreonine
Modified residue (large scale data)713PRIDEPhosphothreonine

Expression

Gene expression databases

    • ENSG00000166598Expressed in right lobe of thyroid gland and 212 other cell types or tissues

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain12-171Histidine kinase/HSP90-like ATPase
Region204-239Disordered
Compositional bias206-230Acidic residues
Region666-719Disordered
Compositional bias670-706Acidic residues

Sequence similarities

Belongs to the heat shock protein 90 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    719
  • Mass (Da)
    83,014
  • Last updated
    2021-06-02 v1
  • Checksum
    A3F9AC8F50F762DA
MMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

Computationally mapped potential isoform sequences

There are 16 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P14625ENPL_HUMANHSP90B1803
H0YIV0H0YIV0_HUMANHSP90B1796
A0A7P0T8C8A0A7P0T8C8_HUMANHSP90B159
A0A7P0T8R3A0A7P0T8R3_HUMANHSP90B1251
A0A7P0T823A0A7P0T823_HUMANHSP90B1813
A0A7P0T885A0A7P0T885_HUMANHSP90B1274
F8W026F8W026_HUMANHSP90B148
A0A7P0TAT8A0A7P0TAT8_HUMANHSP90B1814
A0A7P0TAY2A0A7P0TAY2_HUMANHSP90B1661
A0A7P0TBC2A0A7P0TBC2_HUMANHSP90B1465
A0A7P0TAC2A0A7P0TAC2_HUMANHSP90B155
A0A7P0TAE1A0A7P0TAE1_HUMANHSP90B1789
A0A7P0TAG4A0A7P0TAG4_HUMANHSP90B153
A0A7P0Z405A0A7P0Z405_HUMANHSP90B1163
A0A7P0Z4B4A0A7P0Z4B4_HUMANHSP90B168
A0A087WT78A0A087WT78_HUMANHSP90B1751

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias206-230Acidic residues
Compositional bias670-706Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC078819
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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