A0A7P0T857 · A0A7P0T857_HUMAN
- ProteinAlkylglycerone-phosphate synthase
- GeneAGPS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids122 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
Catalytic activity
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+
Cofactor
Pathway
Glycerolipid metabolism; ether lipid biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | alkylglycerone-phosphate synthase activity | |
Biological Process | ether lipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkylglycerone-phosphate synthase
- EC number
- Short namesAlkyl-DHAP synthase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7P0T857
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 138 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 42 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 65 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 68 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 72 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 74 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 80 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 82 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSG | ||||||
Compositional bias | 23-39 | Basic and acidic residues | ||||
Sequence: ADRDRDPDPDRAGRRLR | ||||||
Region | 62-86 | Disordered | ||||
Sequence: RAASAATAAPTATPAAQESGTIPKK |
Sequence similarities
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length122
- Mass (Da)12,859
- Last updated2021-06-02 v1
- ChecksumA9FFDE787F22E33D
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O00116 | ADAS_HUMAN | AGPS | 658 | ||
A0A2R8YEL0 | A0A2R8YEL0_HUMAN | AGPS | 676 | ||
A0A7P0T9C9 | A0A7P0T9C9_HUMAN | AGPS | 341 | ||
A0A7P0T8Q7 | A0A7P0T8Q7_HUMAN | AGPS | 245 | ||
A0A7P0T984 | A0A7P0T984_HUMAN | AGPS | 624 | ||
A0A1B0GWA2 | A0A1B0GWA2_HUMAN | AGPS | 629 | ||
B7Z3Q4 | B7Z3Q4_HUMAN | AGPS | 568 | ||
A0A7P0TAU9 | A0A7P0TAU9_HUMAN | AGPS | 410 | ||
A0A7P0TA54 | A0A7P0TA54_HUMAN | AGPS | 251 | ||
A0A7P0TAL3 | A0A7P0TAL3_HUMAN | AGPS | 638 | ||
B8ZZ81 | B8ZZ81_HUMAN | AGPS | 189 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-39 | Basic and acidic residues | ||||
Sequence: ADRDRDPDPDRAGRRLR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC016762 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC019080 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC073834 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |