A0A7P0T1I0 · A0A7P0T1I0_HUMAN
- ProteinFAT atypical cadherin 4
- GeneFAT4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3240 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Biological Process | homophilic cell adhesion via plasma membrane adhesion molecules |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7P0T1I0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2761-2785 | Helical | ||||
Sequence: LWAVPAIVGSCATVLALLVLSLILC |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,314 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for disulfide bond, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Disulfide bond | 2109↔2118 | UniProt | |||||
Sequence: CLPGYAGSWC | |||||||
Disulfide bond | 2147↔2156 | UniProt | |||||
Sequence: CPDGFTGRAC | |||||||
Disulfide bond | 2185↔2194 | UniProt | |||||
Sequence: CKTGYTGKMC | |||||||
Disulfide bond | 2223↔2232 | UniProt | |||||
Sequence: CPFGVFGKHC | |||||||
Disulfide bond | 2447↔2456 | UniProt | |||||
Sequence: CKEGLTGKYC | |||||||
Disulfide bond | 2712↔2721 | UniProt | |||||
Sequence: CPDSHTGRTC | |||||||
Modified residue (large scale data) | 2914 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2945 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2961 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2975 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 3014 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 3041 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 3135 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-98 | Cadherin | ||||
Sequence: TVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKF | ||||||
Domain | 99-201 | Cadherin | ||||
Sequence: SRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIF | ||||||
Domain | 202-308 | Cadherin | ||||
Sequence: SLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF | ||||||
Domain | 308-411 | Cadherin | ||||
Sequence: FLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIF | ||||||
Domain | 412-516 | Cadherin | ||||
Sequence: AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVF | ||||||
Domain | 517-621 | Cadherin | ||||
Sequence: ELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTF | ||||||
Domain | 622-725 | Cadherin | ||||
Sequence: ASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRF | ||||||
Domain | 726-826 | Cadherin | ||||
Sequence: QHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKV | ||||||
Domain | 827-928 | Cadherin | ||||
Sequence: RAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIF | ||||||
Domain | 929-1032 | Cadherin | ||||
Sequence: KEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF | ||||||
Domain | 1032-1131 | Cadherin | ||||
Sequence: FSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRF | ||||||
Domain | 1132-1242 | Cadherin | ||||
Sequence: SRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQF | ||||||
Domain | 1243-1348 | Cadherin | ||||
Sequence: LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF | ||||||
Domain | 1349-1453 | Cadherin | ||||
Sequence: SQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF | ||||||
Domain | 1454-1557 | Cadherin | ||||
Sequence: LSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRF | ||||||
Domain | 1558-1663 | Cadherin | ||||
Sequence: VSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIF | ||||||
Domain | 1664-1769 | Cadherin | ||||
Sequence: TLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPML | ||||||
Domain | 1768-1879 | Cadherin | ||||
Sequence: MLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIF | ||||||
Domain | 2061-2119 | EGF-like | ||||
Sequence: DHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCE | ||||||
Domain | 2121-2157 | EGF-like | ||||
Sequence: DIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACE | ||||||
Domain | 2159-2195 | EGF-like | ||||
Sequence: DINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCE | ||||||
Domain | 2197-2233 | EGF-like | ||||
Sequence: SVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE | ||||||
Domain | 2234-2418 | Laminin G | ||||
Sequence: LNSYGFEELSYMEFPSLDPNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQC | ||||||
Domain | 2421-2457 | EGF-like | ||||
Sequence: LEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE | ||||||
Domain | 2476-2657 | Laminin G | ||||
Sequence: YHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGIPPNQAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGC | ||||||
Domain | 2685-2722 | EGF-like | ||||
Sequence: PPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCE | ||||||
Compositional bias | 2793-2814 | Basic and acidic residues | ||||
Sequence: AKNPKEEKKPKEKKKKGSENVA | ||||||
Region | 2793-2843 | Disordered | ||||
Sequence: AKNPKEEKKPKEKKKKGSENVAFDDPDNIPPYGDDMTVRKQPEGNPKPDII | ||||||
Region | 2939-2972 | Disordered | ||||
Sequence: QGLRTSSLSHSACPTPNPLSRHSPAPFSKSSTFY | ||||||
Region | 3011-3114 | Disordered | ||||
Sequence: RSKSPQAMASHGSRPGSRLKQPIGQIPLESSPPVGLSIEEVERLNTPRPRNPSICSADHGRSSSEEDCRRPLSRTRNPADGIPAPESSSDSDSHESFTCSEMEY | ||||||
Compositional bias | 3070-3084 | Basic and acidic residues | ||||
Sequence: GRSSSEEDCRRPLSR | ||||||
Region | 3128-3170 | Disordered | ||||
Sequence: KLSQVNESDADDEDNYGARLKPRRYHGRRAEGGPVGTQAAAPG | ||||||
Compositional bias | 3132-3148 | Basic and acidic residues | ||||
Sequence: VNESDADDEDNYGARLK | ||||||
Region | 3216-3240 | Disordered | ||||
Sequence: AAANEEGKAGTTKPVPKDGEAEQYV |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,240
- Mass (Da)353,267
- Last updated2021-06-02 v1
- ChecksumE5201AB1E743D028
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q6V0I7 | FAT4_HUMAN | FAT4 | 4981 | ||
A0A6Q8JR05 | A0A6Q8JR05_HUMAN | FAT4 | 4983 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2793-2814 | Basic and acidic residues | ||||
Sequence: AKNPKEEKKPKEKKKKGSENVA | ||||||
Compositional bias | 3070-3084 | Basic and acidic residues | ||||
Sequence: GRSSSEEDCRRPLSR | ||||||
Compositional bias | 3132-3148 | Basic and acidic residues | ||||
Sequence: VNESDADDEDNYGARLK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC079835 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092629 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC098865 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |