A0A7P0MRI8 · A0A7P0MRI8_HUMAN

  • Protein
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • Gene
    PLCB4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site328
Binding site329Ca2+ (UniProtKB | ChEBI)
Binding site358Ca2+ (UniProtKB | ChEBI)
Binding site360Ca2+ (UniProtKB | ChEBI)
Active site375
Binding site409Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular Componentnucleus
Cellular Componentparallel fiber to Purkinje cell synapse
Cellular Componentpostsynaptic density
Cellular Componentsmooth endoplasmic reticulum
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process
Biological Processmodulation of chemical synaptic transmission

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      PLCB4

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7P0MRI8

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,359 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)521PRIDEPhosphoserine
Modified residue (large scale data)898PRIDEPhosphothreonine
Modified residue (large scale data)901PRIDEPhosphoserine
Modified residue (large scale data)902PRIDEPhosphoserine
Modified residue (large scale data)1199PRIDEPhosphoserine

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region480-511Disordered
Compositional bias492-507Acidic residues
Domain577-693PI-PLC Y-box
Domain696-821C2
Region875-907Disordered
Compositional bias891-907Polar residues
Coiled coil934-997
Region1094-1122Disordered
Compositional bias1105-1122Basic and acidic residues
Region1171-1206Disordered
Compositional bias1190-1206Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,206
  • Mass (Da)
    137,487
  • Last updated
    2021-06-02 v1
  • Checksum
    F42621A2402AF496
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASDDLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN

Computationally mapped potential isoform sequences

There are 27 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q15147PLCB4_HUMANPLCB41175
A0A8I5QJ53A0A8I5QJ53_HUMANPLCB4866
A0A8I5QJE7A0A8I5QJE7_HUMANPLCB41022
A0A8I5QL35A0A8I5QL35_HUMANPLCB41146
A0A8J8Z831A0A8J8Z831_HUMANPLCB41112
B1AJW1B1AJW1_HUMANPLCB459
B1AJW3B1AJW3_HUMANPLCB4110
A0A8I5KQ87A0A8I5KQ87_HUMANPLCB41209
A0A8I5KPQ9A0A8I5KPQ9_HUMANPLCB41080
A0A8I5KQF5A0A8I5KQF5_HUMANPLCB4554
A0A8I5KQI1A0A8I5KQI1_HUMANPLCB41188
A0A8I5KPD4A0A8I5KPD4_HUMANPLCB41105
A0A8I5KS50A0A8I5KS50_HUMANPLCB41176
A0A8I5KRP3A0A8I5KRP3_HUMANPLCB41157
A0A8I5KQZ0A0A8I5KQZ0_HUMANPLCB41179
A0A8I5KR92A0A8I5KR92_HUMANPLCB41122
A0A8I5KRK2A0A8I5KRK2_HUMANPLCB41132
A0A8I5KRA0A0A8I5KRA0_HUMANPLCB41107
A0A8I5KWR8A0A8I5KWR8_HUMANPLCB4484
A0A8I5KX58A0A8I5KX58_HUMANPLCB41074
A0A8I5KVM8A0A8I5KVM8_HUMANPLCB4207
A0A8I5KW09A0A8I5KW09_HUMANPLCB41099
A0A8I5KYY7A0A8I5KYY7_HUMANPLCB41025
A0A8I5KXD7A0A8I5KXD7_HUMANPLCB41164
A0A8I5KX82A0A8I5KX82_HUMANPLCB41120
A0A8I5KXT9A0A8I5KXT9_HUMANPLCB436
A0A8I5KXW3A0A8I5KXW3_HUMANPLCB41043

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias492-507Acidic residues
Compositional bias891-907Polar residues
Compositional bias1105-1122Basic and acidic residues
Compositional bias1190-1206Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL023805
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL031652
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL121898
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL121909
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456812
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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