A0A7P0MRI8 · A0A7P0MRI8_HUMAN
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePLCB4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1206 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | glutamatergic synapse | |
Cellular Component | nucleus | |
Cellular Component | parallel fiber to Purkinje cell synapse | |
Cellular Component | postsynaptic density | |
Cellular Component | smooth endoplasmic reticulum | |
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process | |
Biological Process | modulation of chemical synaptic transmission |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7P0MRI8
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,359 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 521 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 898 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 901 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 902 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1199 | PRIDE | Phosphoserine | ||||
Sequence: S |
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 480-511 | Disordered | ||||
Sequence: MMEAGESASPANILEDDNEEEIESADQEEEAH | ||||||
Compositional bias | 492-507 | Acidic residues | ||||
Sequence: ILEDDNEEEIESADQE | ||||||
Domain | 577-693 | PI-PLC Y-box | ||||
Sequence: LSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMR | ||||||
Domain | 696-821 | C2 | ||||
Sequence: DRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL | ||||||
Region | 875-907 | Disordered | ||||
Sequence: ADVPSDTSKNDKKGKANTAKANVTPQSSSELRP | ||||||
Compositional bias | 891-907 | Polar residues | ||||
Sequence: NTAKANVTPQSSSELRP | ||||||
Coiled coil | 934-997 | |||||
Sequence: LKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKK | ||||||
Region | 1094-1122 | Disordered | ||||
Sequence: KISMENSKAISQDKSIKNKAERERRVREL | ||||||
Compositional bias | 1105-1122 | Basic and acidic residues | ||||
Sequence: QDKSIKNKAERERRVREL | ||||||
Region | 1171-1206 | Disordered | ||||
Sequence: HAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN | ||||||
Compositional bias | 1190-1206 | Polar residues | ||||
Sequence: RDGPQTSNSSMKLQNAN |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,206
- Mass (Da)137,487
- Last updated2021-06-02 v1
- ChecksumF42621A2402AF496
Computationally mapped potential isoform sequences
There are 27 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q15147 | PLCB4_HUMAN | PLCB4 | 1175 | ||
A0A8I5QJ53 | A0A8I5QJ53_HUMAN | PLCB4 | 866 | ||
A0A8I5QJE7 | A0A8I5QJE7_HUMAN | PLCB4 | 1022 | ||
A0A8I5QL35 | A0A8I5QL35_HUMAN | PLCB4 | 1146 | ||
A0A8J8Z831 | A0A8J8Z831_HUMAN | PLCB4 | 1112 | ||
B1AJW1 | B1AJW1_HUMAN | PLCB4 | 59 | ||
B1AJW3 | B1AJW3_HUMAN | PLCB4 | 110 | ||
A0A8I5KQ87 | A0A8I5KQ87_HUMAN | PLCB4 | 1209 | ||
A0A8I5KPQ9 | A0A8I5KPQ9_HUMAN | PLCB4 | 1080 | ||
A0A8I5KQF5 | A0A8I5KQF5_HUMAN | PLCB4 | 554 | ||
A0A8I5KQI1 | A0A8I5KQI1_HUMAN | PLCB4 | 1188 | ||
A0A8I5KPD4 | A0A8I5KPD4_HUMAN | PLCB4 | 1105 | ||
A0A8I5KS50 | A0A8I5KS50_HUMAN | PLCB4 | 1176 | ||
A0A8I5KRP3 | A0A8I5KRP3_HUMAN | PLCB4 | 1157 | ||
A0A8I5KQZ0 | A0A8I5KQZ0_HUMAN | PLCB4 | 1179 | ||
A0A8I5KR92 | A0A8I5KR92_HUMAN | PLCB4 | 1122 | ||
A0A8I5KRK2 | A0A8I5KRK2_HUMAN | PLCB4 | 1132 | ||
A0A8I5KRA0 | A0A8I5KRA0_HUMAN | PLCB4 | 1107 | ||
A0A8I5KWR8 | A0A8I5KWR8_HUMAN | PLCB4 | 484 | ||
A0A8I5KX58 | A0A8I5KX58_HUMAN | PLCB4 | 1074 | ||
A0A8I5KVM8 | A0A8I5KVM8_HUMAN | PLCB4 | 207 | ||
A0A8I5KW09 | A0A8I5KW09_HUMAN | PLCB4 | 1099 | ||
A0A8I5KYY7 | A0A8I5KYY7_HUMAN | PLCB4 | 1025 | ||
A0A8I5KXD7 | A0A8I5KXD7_HUMAN | PLCB4 | 1164 | ||
A0A8I5KX82 | A0A8I5KX82_HUMAN | PLCB4 | 1120 | ||
A0A8I5KXT9 | A0A8I5KXT9_HUMAN | PLCB4 | 36 | ||
A0A8I5KXW3 | A0A8I5KXW3_HUMAN | PLCB4 | 1043 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 492-507 | Acidic residues | ||||
Sequence: ILEDDNEEEIESADQE | ||||||
Compositional bias | 891-907 | Polar residues | ||||
Sequence: NTAKANVTPQSSSELRP | ||||||
Compositional bias | 1105-1122 | Basic and acidic residues | ||||
Sequence: QDKSIKNKAERERRVREL | ||||||
Compositional bias | 1190-1206 | Polar residues | ||||
Sequence: RDGPQTSNSSMKLQNAN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL023805 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL031652 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL121898 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL121909 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF456812 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |