A0A7N9DDJ7 · A0A7N9DDJ7_MACFA

Function

function

Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentmembrane raft
Molecular Functiondelayed rectifier potassium channel activity
Molecular Functionpotassium channel regulator activity
Molecular Functiontransmembrane transporter binding
Molecular Functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Processnegative regulation of delayed rectifier potassium channel activity
Biological Processpotassium ion export across plasma membrane
Biological Processregulation of heart rate by cardiac conduction
Biological Processregulation of ventricular cardiac muscle cell membrane repolarization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Potassium voltage-gated channel subfamily E member 1

Organism names

Accessions

  • Primary accession
    A0A7N9DDJ7

Proteomes

Subcellular Location

Apical cell membrane
Cell membrane
; Single-pass type I membrane protein
Membrane raft

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane259-281Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region100-162Disordered

Sequence similarities

Belongs to the potassium channel KCNE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    37,028
  • Last updated
    2021-06-02 v1
  • Checksum
    C5471BF926A17B28
ICRWVGFLDPNADILPALSLSNRIQSASSQAEALVWGAGCGGSGWAGAGLGWSRGTLGWAVSVGGVGRDAWRLWEALPVPAPRAALRPLEGAAPGLGCRWPQRSAGARSAPHPALRISDPGKSGAPTSAALSRGASGLVGQLRGPLEPASPDAQRARSRLEAPRLPEWETGFTQSSGEPRIHWRTALSVSRGNSQGYSEVCLGSWSSSSGTLMPRMILSNTTAVTPFLTKLWQETVQQGSNMSGLARRSPRSDDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQKKDKAYVQSRVLESYRACYVVENHLAVEQPNTQLPETKPSP

Keywords

Genome annotation databases

Similar Proteins

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