A0A7N9CC80 · A0A7N9CC80_MACFA

Function

Catalytic activity

  • (E)-4-hydroxynon-2-enal + NAD+ + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 13-cis-retinal + NAD+ + H2O = 13-cis-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 3-deoxyglucosone + NAD+ + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.19 (UniProtKB | ENZYME | Rhea)
  • 9-cis-retinal + NAD+ + H2O = 9-cis-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • propanal + NAD+ + H2O = propanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • malonaldehyde + NAD+ + H2O = 3-oxopropanoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
  • acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.36 (UniProtKB | ENZYME | Rhea)
  • an aldehyde + NAD+ + H2O = a carboxylate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • benzaldehyde + NAD+ + H2O = benzoate + NADH + 2 H+
    This reaction proceeds in the forward direction.
    EC:1.2.1.28 (UniProtKB | ENZYME | Rhea)

Pathway

Cofactor metabolism; retinol metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site295

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3-deoxyglucosone dehydrogenase activity
Molecular Functionbenzaldehyde dehydrogenase (NAD+) activity
Biological Processcellular detoxification of aldehyde
Biological Processfructosamine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde dehydrogenase 1A1
  • EC number
  • Alternative names
    • 3-deoxyglucosone dehydrogenase
    • ALDH-E1
    • ALHDII
    • Aldehyde dehydrogenase family 1 member A1
    • Aldehyde dehydrogenase, cytosolic
    • Retinal dehydrogenase 1

Gene names

    • Name
      ALDH1A1

Organism names

Accessions

  • Primary accession
    A0A7N9CC80

Proteomes

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homotetramer. Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-34Basic and acidic residues
Region1-37Disordered
Domain55-518Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    57,878
  • Last updated
    2021-06-02 v1
  • Checksum
    ABEC5528C68AF4CA
MPDRGKGDMCLVEKRRWEGRNGADDQDGKRDLQTPREPTTCSFTALQEIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q4R5G3Q4R5G3_MACFAALDH1A1501
A0A7N9ICN8A0A7N9ICN8_MACFAALDH1A1481
A0A7N9C970A0A7N9C970_MACFAALDH1A1495
A0A7N9CLZ3A0A7N9CLZ3_MACFAALDH1A1463
A0A2K5WPH2A0A2K5WPH2_MACFAALDH1A1298
A0A2K5WP74A0A2K5WP74_MACFAALDH1A1230
A0A7N9CZ59A0A7N9CZ59_MACFAALDH1A1511

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-34Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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