A0A7N5K1S6 · A0A7N5K1S6_AILME

Function

function

GTPase-activating protein for the ADP ribosylation factor family.

Activity regulation

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome membrane
Molecular FunctionGTPase activator activity
Molecular Functionmetal ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
  • Short names
    Cnt-b
  • Alternative names
    • Centaurin-beta

Gene names

    • Name
      ACAP3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ailuropoda

Accessions

  • Primary accession
    A0A7N5K1S6

Proteomes

Subcellular Location

Endosome membrane
; Peripheral membrane protein

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

Type
IDPosition(s)Description
Domain142-237PH
Region249-276Disordered
Compositional bias250-267Polar residues
Domain277-399Arf-GAP
Region393-426Disordered
Repeat522-554ANK
Repeat555-587ANK

Domain

PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    659
  • Mass (Da)
    72,874
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    CC5F6E29018EA9129B39D659B6838A1E
EPQARGGPVCSQLRCCYRATIEEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQQCQGDTVISVRGQLVSLGKCVHLPPGAPPPQLDQLVIDSAVEKRDMERKHAAIQQRDFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDVLTVVVEDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDSRERSVKGESVLQRVQNVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGQGSRKPTASSPRQDKEAWIKDKYVEKKFLRKPPSAPAREAPRHWQAQKCQHHHSSPRRHRGGWVRASLPLLQPSPRPPLTPLQARSWPLTIPLPVEGAESEESSGEADDGEAEAWGLADVRELHPGLLAHRAARTRDLPALATALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDHEQQDPLSIAIQEANADIVTLLRLARMAEEMREAEAPPGQPGPLAGSSPTELQYRRCMQDQCIKDFGTFHPCI

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7N5JYW4A0A7N5JYW4_AILMEACAP3780
A0A7N5JYL9A0A7N5JYL9_AILMEACAP3632
G1M558G1M558_AILMEACAP3742
A0A7N5P0X3A0A7N5P0X3_AILMEACAP3639
A0A7N5JJC8A0A7N5JJC8_AILMEACAP3661
A0A7N5KNF5A0A7N5KNF5_AILMEACAP3563
A0A7N5K9P8A0A7N5K9P8_AILMEACAP3685

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias250-267Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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