A0A7M7RGA0 · A0A7M7RGA0_STRPU

Function

Catalytic activity

  • 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = glycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site448

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functiondiacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Molecular Functionmonoacylglycerol lipase activity
Molecular Functiontriacylglycerol lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Organism names

Accessions

  • Primary accession
    A0A7M7RGA0

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer and homodimer. Interacts with CAVIN1 in the adipocyte cytoplasm. Interacts with PLIN5.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain28-333Hormone-sensitive lipase N-terminal
Domain370-518Alpha/beta hydrolase fold-3
Region534-599Disordered
Compositional bias550-565Basic and acidic residues
Compositional bias618-636Polar residues
Region618-692Disordered
Domain728-790Alpha/beta hydrolase fold-3

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    827
  • Mass (Da)
    91,213
  • Last updated
    2021-04-07 v1
  • Checksum
    8621485CA783EC7A
MASFQRQSSAISNASSSSFMDNSVLLSISTLRQLIINNIEYFQKLRSSTGEKFYTLFCVIEQEADAMRPTVEALERISHNFDFDPKVPGNGYRSLVQVVDACVDRLIKVVRSISQTRESYLFRSGFHLKELESYGAVLGQLRVILGYAQKLVAYSEPGNLFPNNDEQFPENVMLEVQALDRECFYGRCLGFQFCESLWQPLQTVAVALASYAEGYQKYEGPFSRVASSFFHSGRYLTNPEARGKQILDITNKSDIRFCKAFWSITEGDVIAEMCNLMAGSVAVNKLIQIQPHNFEMERSDGEGETATITPPCAHTGPAPVQIRLLCFVEREGQGWLNEAEEIAFQQMGKSSKKAKQKIEKPPSPMSKGLLIHIHGGGFVAHTSKSHEIYLRSWAKDLGVPIVSIDYSLAPEQPFPRAFEECFFAYAWAVKNAPYLGSTGEHICLAGDSSGGNLCTAVAMRAASYGIQVPDGIVTMYTPFAVHHSASPSRLLCLLDPLLPFGVLMRCLSAYVDLKEEFMTEEKVTSMVDNANDRILGSPKRSSMKSGEGSPVVGEKEEKIEEEENGNSTKVTTPTTTKEGVNGDIIVPPPSDSVSSFMEEVPPTDIEKLEQVSDAIDNATIGQGDGQTDTNGEQSSPEAIAIFDPSHPPNTADHPNSLPADIDAISLDSKPEADREEEDEEDSVPLSPKSREDLHLDLKEEGLAGDEEVQTPTSFVNSPIRVFKDAPIMRNPYVSPLFSDEELLKGLPPVHIIGCALDPLLDDSISFAKKLRGMGKPVFLEIVNQLPHGFLNFSTVGKECKEASMVCVRHIMHVLYGFQDNDFENLGD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7M7GLE4A0A7M7GLE4_STRPU835

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias550-565Basic and acidic residues
Compositional bias618-636Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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