A0A7M7RGA0 · A0A7M7RGA0_STRPU
- ProteinHormone-sensitive lipase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids827 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H+This reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 448 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | diacylglycerol lipase activity | |
Molecular Function | hormone-sensitive lipase activity | |
Molecular Function | monoacylglycerol lipase activity | |
Molecular Function | triacylglycerol lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | triglyceride catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Camarodonta > Echinidea > Strongylocentrotidae > Strongylocentrotus
Accessions
- Primary accessionA0A7M7RGA0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer and homodimer. Interacts with CAVIN1 in the adipocyte cytoplasm. Interacts with PLIN5.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 28-333 | Hormone-sensitive lipase N-terminal | |||
Domain | 370-518 | Alpha/beta hydrolase fold-3 | |||
Region | 534-599 | Disordered | |||
Compositional bias | 550-565 | Basic and acidic residues | |||
Compositional bias | 618-636 | Polar residues | |||
Region | 618-692 | Disordered | |||
Domain | 728-790 | Alpha/beta hydrolase fold-3 | |||
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length827
- Mass (Da)91,213
- Last updated2021-04-07 v1
- Checksum8621485CA783EC7A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7M7GLE4 | A0A7M7GLE4_STRPU | 835 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 550-565 | Basic and acidic residues | |||
Compositional bias | 618-636 | Polar residues | |||
Keywords
- Technical term