A0A7M7PCG7 · A0A7M7PCG7_STRPU
- ProteinProton-coupled folate transporter
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids504 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H+(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H+(out)
- folate(in) + H+(in) = folate(out) + H+(out)
- methotrexate(in) + H+(in) = methotrexate(out) + H+(out)
- pemetrexed(in) + H+(in) = pemetrexed(out) + H+(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | endosome membrane | |
Cellular Component | plasma membrane | |
Molecular Function | folic acid binding | |
Molecular Function | symporter activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | transmembrane transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProton-coupled folate transporter
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Echinacea > Camarodonta > Echinidea > Strongylocentrotidae > Strongylocentrotus
Accessions
- Primary accessionA0A7M7PCG7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Basolateral cell membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 39-57 | Helical | |||
Transmembrane | 136-155 | Helical | |||
Transmembrane | 161-190 | Helical | |||
Transmembrane | 202-225 | Helical | |||
Transmembrane | 231-252 | Helical | |||
Transmembrane | 287-310 | Helical | |||
Transmembrane | 322-341 | Helical | |||
Transmembrane | 353-372 | Helical | |||
Transmembrane | 411-433 | Helical | |||
Transmembrane | 445-464 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-29 | Disordered | |||
Compositional bias | 7-27 | Polar residues | |||
Domain | 40-469 | Major facilitator superfamily (MFS) profile | |||
Compositional bias | 481-491 | Polar residues | |||
Region | 481-504 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length504
- Mass (Da)55,551
- Last updated2021-04-07 v1
- MD5 Checksum9471234C36902135CC9D6C11573240A4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7M7PEG5 | A0A7M7PEG5_STRPU | 448 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 7-27 | Polar residues | |||
Compositional bias | 481-491 | Polar residues | |||
Keywords
- Technical term