A0A7M7LVS1 · A0A7M7LVS1_STRPU

Function

Catalytic activity

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
    EC:3.1.11.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

162450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site32Mg2+ 1 (UniProtKB | ChEBI)
Binding site59Mg2+ 1 (UniProtKB | ChEBI)
Active site172
Active site213Proton donor/acceptor
Binding site213Mg2+ 1 (UniProtKB | ChEBI)
Binding site215Mg2+ 1 (UniProtKB | ChEBI)
Site215Transition state stabilizer
Site334Important for catalytic activity
Binding site360Mg2+ 1 (UniProtKB | ChEBI)
Active site361Proton acceptor
Binding site361Mg2+ 1 (UniProtKB | ChEBI)
Site361Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease
  • EC number

Organism names

Accessions

  • Primary accession
    A0A7M7LVS1

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_502963529317-624DNA-(apurinic or apyrimidinic site) endonuclease

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region252-290Disordered
Compositional bias267-290Basic and acidic residues
Region415-451Disordered
Region470-507Disordered
Compositional bias475-504Polar residues
Domain569-618GRF-type

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    624
  • Mass (Da)
    69,747
  • Last updated
    2021-04-07 v1
  • Checksum
    DB61494E31D432B0
MCLTLAWHVVLSRSLSIHIPCSLTKMKVLTWNINGLRACKVPLKELFANLDADIICLQETKITRDQLDNDLVNVDDYNAYFSFSKKRSGYSGVATYCKNSTTPVIAEEGLTGLLSHGTKQSLIGCYGDQSAYSPEELLSIDAEGRTIITQHQYRYKGKKDGALGDLVIINVYCPRAGDDNPERKSFKMRFYNLLQLRAEAMLQAGKSVVIVGDVNASHRRIDHCDPSGNWGKFESHPSRKWLDGFLKDCSCPETAETSPSSQDDLQKSPQEEQELSDEERHVHDDSNIDVEDIPSKDNLFVDSFRYFHPKRENAFTCWSTLTGARQTNYGTRIDYIIVNERLCVDELTECDIMPEFEGSDHCPVKATLLGGCSPAEQLHPMCAKLMPEVAGKQQKLSNFFQKVSPSKKFEMHEKAMSGENKQGGRSRLDIGKREGQSLVGKPGKRAKTDGKVTKTGNIASFFKKKADAKLRSQTDLEIHQSSSSSYNTRLMPNSQRSDGDIDNGSDFQNRLKDIPVDSGISGSDDAVSDASQIVKETSQELFEDKPKAKQQLASAWKNLFKGPPPSPMCKGHQEPCLLRTVKKAGPNLGKQFFVCKRPEGHKNNPEARCNHFEWVSKKLNLKSV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7M7RDG5A0A7M7RDG5_STRPU621

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias267-290Basic and acidic residues
Compositional bias475-504Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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