A0A7M6UNC0 · A0A7M6UNC0_APIME

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

112921002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site381Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site381Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site381-386ATP (UniProtKB | ChEBI)
Binding site382Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site423-425ATP (UniProtKB | ChEBI)
Binding site425Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site425Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site469ATP (UniProtKB | ChEBI)
Binding site1117ATP (UniProtKB | ChEBI)
Binding site1193-1195ATP (UniProtKB | ChEBI)
Binding site1200-1204ATP (UniProtKB | ChEBI)
Binding site1240ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Gene names

    • Name
      ac8
    • Synonyms
      LOC726262

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis

Accessions

  • Primary accession
    A0A7M6UNC0
  • Secondary accessions
    • A0A8B6X0H1
    • I4EC01

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane131-151Helical
Transmembrane163-183Helical
Transmembrane190-208Helical
Transmembrane220-237Helical
Transmembrane691-712Helical
Transmembrane718-739Helical
Transmembrane764-784Helical
Transmembrane923-942Helical
Transmembrane949-969Helical
Transmembrane981-999Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region42-64Disordered
Domain376-503Guanylate cyclase
Region579-602Disordered
Compositional bias581-601Polar residues
Region838-859Disordered
Domain1067-1206Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,292
  • Mass (Da)
    146,635
  • Last updated
    2023-06-28 v1
  • Checksum
    42423E3EF8F59280
MRHIINTITLFGVSISPRKQLWIKAVKKLTSERLGREGLAAWEDRKSNNDPEVPDINETTNPIEDADISTDPDVVLAEEPVDTESQAQRDVFKKGVLYKGIFCPSLSNSFHSKQLETSYLHYSNRQRQKSLIMLNIVDLSLKIILMAIWLWKRDKNSSGLVESLSWVSCCMAANLVVCILGWWRCFSNNYLYWASIFTWLLINSQGFIGAGLDFSSQQRLMWYILFVVYAPYAMLPLPLRWCVLAGYGTALTHMVMAGITLLRDPTYLHDITCIVRMLTTNVLLYLAMNLAGMYTKYLTDRGQRQAFLETHRSMETRQRTQNENNRQEKLLLSVLPDFVAKEMIRDIARETARGGTISFTPNQFHRIYIHRYENVSILFADIKGFTALASQCSAQELVKVLNDLFARFDKLSAENHCLRIKLLGDCYYCICGLPIARSDHAHCCVEMGLHMIKAIRDVRYTTKVDLNMRIGIHSGSVLCGVLGLRKWQFDVWSYDVTLANHLESGGIPGRVHISEDTLNCLNDVYEVEPGNGTERDNYLKERNVVTYLIKQVEPLRSRRRYSSRPKIWSEDDMNKGKKSFKLNNPLATNSSAPNSSTEDDIGVDWTPEIPFENLNTATSVSNLESEYLEEENGSAKSNKAVSAASVEKLKTAGLETASNKRMRSANINAWTLRYNDESLESKFGQLREDMFKSNMICCFVVWIFIAICQAVILPDCIILLGSLLLTTLILVASSILVMAEEFKTLPTYLQHASSMLVHNKQHRTIFICSVISLMALTSIVSVLACPMSIRQYPEALELQQQPLMNPTLQPERLVAPTVGLDQFILTFLEAALRDESSEEQKDVSSKENQTVSHSSNDEELQTNLIKARASLAKGQRRKEFFRDEDIISGRILSTSETKPQVESLYSLDYDEDIVLGTCVRPEYIVFTWILCLIALASALKLYYLVKTALATIIVSIYAVLILVVCKDFFTVPNEEDSMSIPLSAQMLTFLLVFLVMVTYHGRLVEVTSRLDFLWKQQAERELSDMIESRHNNMQLLKNILPDHVAHHFLTQDRAPEELYSQSRDKVGVMFASVPNFTEFYSEDVNKGMECIRLLNEIIADFDELLDENRFHCIEKIKTVGATYMAASGLNPCQNDKNKDDMEHLCRLVDYAVAMRLRLEDVNIHSFNNFDLRVGISCGPLVGGVIGARKPVFDIWGNTVNLASRMDSTGVMGKIQVPQDIARFLESRGYQTQKRGLIEVKGKGTMETYFVLGKGTLQQESSTKHTARCRSLAAVVYGVVQARRKQMRALRRT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias581-601Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE611296
EMBL· GenBank· DDBJ
CCE60554.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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