A0A7M6UNC0 · A0A7M6UNC0_APIME
- Proteinadenylate cyclase
- Geneac8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1292 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 381 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 381 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 381-386 | ATP (UniProtKB | ChEBI) | |||
Binding site | 382 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 423-425 | ATP (UniProtKB | ChEBI) | |||
Binding site | 425 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 425 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 469 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1117 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1193-1195 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1200-1204 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1240 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis
Accessions
- Primary accessionA0A7M6UNC0
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 131-151 | Helical | |||
Transmembrane | 163-183 | Helical | |||
Transmembrane | 190-208 | Helical | |||
Transmembrane | 220-237 | Helical | |||
Transmembrane | 691-712 | Helical | |||
Transmembrane | 718-739 | Helical | |||
Transmembrane | 764-784 | Helical | |||
Transmembrane | 923-942 | Helical | |||
Transmembrane | 949-969 | Helical | |||
Transmembrane | 981-999 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 42-64 | Disordered | |||
Domain | 376-503 | Guanylate cyclase | |||
Region | 579-602 | Disordered | |||
Compositional bias | 581-601 | Polar residues | |||
Region | 838-859 | Disordered | |||
Domain | 1067-1206 | Guanylate cyclase | |||
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,292
- Mass (Da)146,635
- Last updated2023-06-28 v1
- Checksum42423E3EF8F59280
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 581-601 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE611296 EMBL· GenBank· DDBJ | CCE60554.1 EMBL· GenBank· DDBJ | mRNA |